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Point-of-care measurements reveal release of purines into venous blood of stroke patients

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Dale, Nicholas, Tian, Faming, Sagoo, Ravjit, Phillips, Norman, Imray, C. (Chris) and Roffe, Christine (2019) Point-of-care measurements reveal release of purines into venous blood of stroke patients. Purinergic Signalling, 15 . pp. 237-246. doi:10.1007/s11302-019-09647-4

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Official URL: http://dx.doi.org/10.1007/s11302-019-09647-4

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Abstract

Stroke is a leading cause of death and disability. Here, we examine whether point-of-care measurement of the purines, adenosine, inosine and hypoxanthine, which are downstream metabolites of ATP, has potential to assist the diagnosis of stroke. In a prospective observational study, patients who were suspected of having had a stroke, within 4.5 h of symptom onset and still displaying focal neurological symptoms at admission, were recruited. Clinical research staff in the Emergency Departments of two hospitals used a prototype biosensor array, SMARTCap, to measure the purines in the venous blood of stroke patients and healthy controls. In controls, the baseline purines were 7.1 ± (SD) 4.2 μM (n = 52), while in stroke patients, they were 11.6 ± 8.9 μM (n = 76). Using the National Institutes for Stoke Scale (NIHSS) to band the severity of stroke, we found that minor, moderate and severe strokes all gave significant elevation of blood purines above the controls. The purine levels fall over 24 h. This was most marked for patients with haemorrhagic strokes (5.1 ± 3.6 μM, n = 9 after 24 h). The purine levels measured on admission show a significant correlation with the volume of affected brain tissue determined by medical imaging in patients who had not received thrombolysis or mechanical thrombectomy.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Cerebrovascular disease -- Patients, Purines
Journal or Publication Title: Purinergic Signalling
Publisher: Springer Netherlands
ISSN: 1573-9538
Official Date: 15 June 2019
Dates:
DateEvent
15 June 2019Published
12 March 2019Available
31 January 2019Accepted
Volume: 15
Page Range: pp. 237-246
DOI: 10.1007/s11302-019-09647-4
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
II-LA-0313-20002[NIHR] National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
UNSPECIFIEDUniversity Hospitals Coventry and Warwickshire NHS Trusthttp://viaf.org/viaf/152707181

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