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Hapln2 in neurological diseases and its potential as therapeutic target

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Wang, Qinqin, Wang, Chunmei, Ji, Bingyuan, Zhou, Jiawei, Yang, Chunqing and Chen, Jing (2019) Hapln2 in neurological diseases and its potential as therapeutic target. Frontiers in Aging Neuroscience, 11 . 60. doi:10.3389/fnagi.2019.00060

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Official URL: https://doi.org/10.3389/fnagi.2019.00060

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Abstract

Hyaluronan and proteoglycan link protein 2 (Hapln2) is important for the binding of chondroitin sulfate proteoglycans to hyaluronan. Hapln2 deficiency leads to the abnormal expression of extracellular matrix (ECM) proteins and dysfunctional neuronal conductivity, demonstrating the vital role of Hapln2 in these processes. Studies have revealed that Hapln2 promotes the aggregation of α-synuclein, thereby contributing to neurodegeneration in Parkinson’s disease (PD), and it was recently suggested to be in intracellular neurofibrillary tangles (NFTs). Additionally, the expression levels of Hapln2 showed lower in the anterior temporal lobes of individuals with schizophrenia than those of healthy subjects. Together, these studies implicate the involvement of Hapln2 in the pathological processes of neurological diseases. A better understanding of the function of Hapln2 in the central nervous system (CNS) will provide new insights into the molecular mechanisms of these diseases and help to establish promising therapeutic strategies. Herein, we review the recent progress in defining the role of Hapln2 in brain physiology and pathology.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Medicine > Warwick Medical School
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Parkinson's disease -- Physiological aspects, Alzheimer's disease -- Physiological aspects, Schizophrenia -- Physiological aspects, Nervous system -- Diseases
Journal or Publication Title: Frontiers in Aging Neuroscience
Publisher: Frontiers Media S.A.
ISSN: 1663-4365
Official Date: 21 March 2019
Dates:
DateEvent
21 March 2019Published
1 March 2019Accepted
Volume: 11
Article Number: 60
DOI: 10.3389/fnagi.2019.00060
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
JY2017KJ036Jining Medical Universityhttp://dx.doi.org/10.13039/501100008853
Research Fund for the Doctoral ProgramJining Medical Universityhttp://dx.doi.org/10.13039/501100008853
J18KA124Shandong University of Science and Technologyhttp://dx.doi.org/10.13039/501100004295
JYHL2018MS03Jining Medical Universityhttp://dx.doi.org/10.13039/501100008853
81501018[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
ZR2018MC005Natural Science Foundation of Shandong Provincehttp://dx.doi.org/10.13039/501100007129
J15LE19Department of Education of Shandong Provincehttp://dx.doi.org/10.13039/100012906
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