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Hapln2 in neurological diseases and its potential as therapeutic target
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Wang, Qinqin, Wang, Chunmei, Ji, Bingyuan, Zhou, Jiawei, Yang, Chunqing and Chen, Jing (2019) Hapln2 in neurological diseases and its potential as therapeutic target. Frontiers in Aging Neuroscience, 11 . 60. doi:10.3389/fnagi.2019.00060
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Official URL: https://doi.org/10.3389/fnagi.2019.00060
Abstract
Hyaluronan and proteoglycan link protein 2 (Hapln2) is important for the binding of chondroitin sulfate proteoglycans to hyaluronan. Hapln2 deficiency leads to the abnormal expression of extracellular matrix (ECM) proteins and dysfunctional neuronal conductivity, demonstrating the vital role of Hapln2 in these processes. Studies have revealed that Hapln2 promotes the aggregation of α-synuclein, thereby contributing to neurodegeneration in Parkinson’s disease (PD), and it was recently suggested to be in intracellular neurofibrillary tangles (NFTs). Additionally, the expression levels of Hapln2 showed lower in the anterior temporal lobes of individuals with schizophrenia than those of healthy subjects. Together, these studies implicate the involvement of Hapln2 in the pathological processes of neurological diseases. A better understanding of the function of Hapln2 in the central nervous system (CNS) will provide new insights into the molecular mechanisms of these diseases and help to establish promising therapeutic strategies. Herein, we review the recent progress in defining the role of Hapln2 in brain physiology and pathology.
| Item Type: | Journal Article | ||||||||||||||||||||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||||||||||||||||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | ||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Parkinson's disease -- Physiological aspects, Alzheimer's disease -- Physiological aspects, Schizophrenia -- Physiological aspects, Nervous system -- Diseases | ||||||||||||||||||||||||
| Journal or Publication Title: | Frontiers in Aging Neuroscience | ||||||||||||||||||||||||
| Publisher: | Frontiers Media S.A. | ||||||||||||||||||||||||
| ISSN: | 1663-4365 | ||||||||||||||||||||||||
| Official Date: | 21 March 2019 | ||||||||||||||||||||||||
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| Volume: | 11 | ||||||||||||||||||||||||
| Article Number: | 60 | ||||||||||||||||||||||||
| DOI: | 10.3389/fnagi.2019.00060 | ||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||||||||||||||
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