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Employing paramagnetic shift for responsive MRI probes
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Harnden, Alice C., Parker, David and Rogers, Nicola J. (2019) Employing paramagnetic shift for responsive MRI probes. Coordination Chemistry Reviews, 383 . pp. 30-42. doi:10.1016/j.ccr.2018.12.012 ISSN 0010-8545.
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Official URL: https://doi.org/10.1016/j.ccr.2018.12.012
Abstract
Paramagnetic metal ions with anisotropic magnetic susceptibilities can shift the proton NMR signals of chelating ligands beyond the diamagnetic range of endogenous proton resonances. Such large shifts, along with enhanced longitudinal relaxation rates, allow paramagnetic complexes to be exploited as molecular imaging probes for MRI. Paramagnetically-shifted imaging probes are detected directly against zero background, as opposed to the indirect induced relaxation enhancement of surrounding water molecules, and are reviewed herein. The development of ‘smart’ probes that are sensitive to their surrounding environment is also being developed, and some of the challenges faced for in vivo imaging are discussed, including issues of sensitivity and dose, biodistribution and clearance. Several examples of lanthanide complexes have been investigated, and more recently certain paramagnetic transition metal complexes are being considered as potential imaging agents.
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QC Physics | |||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||
Library of Congress Subject Headings (LCSH): | Nuclear magnetic resonance, Magnetic resonance imaging | |||||||||
Journal or Publication Title: | Coordination Chemistry Reviews | |||||||||
Publisher: | Elsevier BV | |||||||||
ISSN: | 0010-8545 | |||||||||
Official Date: | 15 March 2019 | |||||||||
Dates: |
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Volume: | 383 | |||||||||
Page Range: | pp. 30-42 | |||||||||
DOI: | 10.1016/j.ccr.2018.12.012 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||
Copyright Holders: | Nicola Rogers | |||||||||
Date of first compliant deposit: | 4 April 2019 | |||||||||
Date of first compliant Open Access: | 8 January 2020 | |||||||||
RIOXX Funder/Project Grant: |
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