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Your input is a breath of fresh air! A chemosensory microcircuit of medullary raphe and RTN neurons
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Huckstepp, Robert T. R. (2019) Your input is a breath of fresh air! A chemosensory microcircuit of medullary raphe and RTN neurons. The Journal of Physiology, 597 (10). pp. 2609-2610. doi:10.1113/JP277972 ISSN 0022-3751.
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Official URL: http://dx.doi.org/10.1113/JP277972
Abstract
Breathing is our first act upon birth and the last action we complete before death. The first to last breath taken, is in fact, how we define someone’s life. Since it was first reported that the blood concentration of CO2istightly controlled, and provides the dominant drive to breathe, the search for the cells that regulate it began. It took almost 60 years for the identification of the first central chemosensitive areas, regions within the brain that respond to specific chemical stimuli (such as CO2or its proxy H+), found at the ventrolateral surface of the medulla (VLM). Since then the debate over which cells in these areas are responsible for detectingCO2and signalling its fluctuations to the respiratory oscillators, has been extensive and heated. Chemosensitive cells are thought to have cell bodies located in, or close to, the VLM with dendrites in close apposition to blood vessels to better detect changes in blood gases. Several candidates fulfil this criteria, including the retrotrapezoid nucleus (RTN) and medullary raphe.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QP Physiology | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
Library of Congress Subject Headings (LCSH): | Respiration -- Regulation | ||||||||
Journal or Publication Title: | The Journal of Physiology | ||||||||
Publisher: | Blackwell | ||||||||
ISSN: | 0022-3751 | ||||||||
Official Date: | 15 May 2019 | ||||||||
Dates: |
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Volume: | 597 | ||||||||
Number: | 10 | ||||||||
Page Range: | pp. 2609-2610 | ||||||||
DOI: | 10.1113/JP277972 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Reuse Statement (publisher, data, author rights): | "This is the peer reviewed version of the following article: Huckstepp, R. T. (2019), Your input is a breath of fresh air! A chemosensory microcircuit of medullary raphe and RTN neurons. J Physiol. which has been published in final form at http://dx.doi.org/10.1113/JP277972 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions." | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 5 April 2019 | ||||||||
Date of first compliant Open Access: | 2 April 2020 |
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