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Your input is a breath of fresh air! A chemosensory microcircuit of medullary raphe and RTN neurons
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Huckstepp, Robert T. R. (2019) Your input is a breath of fresh air! A chemosensory microcircuit of medullary raphe and RTN neurons. The Journal of Physiology . doi:10.1113/JP277972 (In Press)
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WRAP-input-breath-fresh-air-chemosensory-microcircuit-medullary-raphe-Huckstepp-2019.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only until 2 April 2020. Contact author directly, specifying your specific needs. - Requires a PDF viewer. Download (668Kb) |
Official URL: http://dx.doi.org/10.1113/JP277972
Abstract
Breathing is our first act upon birth and the last action we complete before death. The first to last breath taken, is in fact, how we define someone’s life. Since it was first reported that the blood concentration of CO2istightly controlled, and provides the dominant drive to breathe, the search for the cells that regulate it began. It took almost 60 years for the identification of the first central chemosensitive areas, regions within the brain that respond to specific chemical stimuli (such as CO2or its proxy H+), found at the ventrolateral surface of the medulla (VLM). Since then the debate over which cells in these areas are responsible for detectingCO2and signalling its fluctuations to the respiratory oscillators, has been extensive and heated. Chemosensitive cells are thought to have cell bodies located in, or close to, the VLM with dendrites in close apposition to blood vessels to better detect changes in blood gases. Several candidates fulfil this criteria, including the retrotrapezoid nucleus (RTN) and medullary raphe.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology | ||||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Respiration -- Regulation | ||||||||
| Journal or Publication Title: | The Journal of Physiology | ||||||||
| Publisher: | Blackwell | ||||||||
| ISSN: | 0022-3751 | ||||||||
| Official Date: | 2019 | ||||||||
| Dates: |
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| Date of first compliant deposit: | 5 April 2019 | ||||||||
| DOI: | 10.1113/JP277972 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | In Press | ||||||||
| Publisher Statement: | "This is the peer reviewed version of the following article: Huckstepp, R. T. (2019), Your input is a breath of fresh air! A chemosensory microcircuit of medullary raphe and RTN neurons. J Physiol. which has been published in final form at http://dx.doi.org/10.1113/JP277972 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions." | ||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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