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Your input is a breath of fresh air! A chemosensory microcircuit of medullary raphe and RTN neurons

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Huckstepp, Robert T. R. (2019) Your input is a breath of fresh air! A chemosensory microcircuit of medullary raphe and RTN neurons. The Journal of Physiology, 597 (10). pp. 2609-2610. doi:10.1113/JP277972

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Official URL: http://dx.doi.org/10.1113/JP277972

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Abstract

Breathing is our first act upon birth and the last action we complete before death. The first to last breath taken, is in fact, how we define someone’s life. Since it was first reported that the blood concentration of CO2istightly controlled, and provides the dominant drive to breathe, the search for the cells that regulate it began. It took almost 60 years for the identification of the first central chemosensitive areas, regions within the brain that respond to specific chemical stimuli (such as CO2or its proxy H+), found at the ventrolateral surface of the medulla (VLM). Since then the debate over which cells in these areas are responsible for detectingCO2and signalling its fluctuations to the respiratory oscillators, has been extensive and heated. Chemosensitive cells are thought to have cell bodies located in, or close to, the VLM with dendrites in close apposition to blood vessels to better detect changes in blood gases. Several candidates fulfil this criteria, including the retrotrapezoid nucleus (RTN) and medullary raphe.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Respiration -- Regulation
Journal or Publication Title: The Journal of Physiology
Publisher: Blackwell
ISSN: 0022-3751
Official Date: 15 May 2019
Dates:
DateEvent
15 May 2019Published
2 April 2019Available
1 April 2019Accepted
Volume: 597
Number: 10
Page Range: pp. 2609-2610
DOI: 10.1113/JP277972
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: "This is the peer reviewed version of the following article: Huckstepp, R. T. (2019), Your input is a breath of fresh air! A chemosensory microcircuit of medullary raphe and RTN neurons. J Physiol. which has been published in final form at http://dx.doi.org/10.1113/JP277972 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."
Access rights to Published version: Restricted or Subscription Access

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