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(Pro)renin receptor-mediated myocardial injury, apoptosis, and inflammatory response in rats with diabetic cardiomyopathy
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Dong, Xuefei, Yu, Shiran, Wang, Ying, Yang, Min, Xiong, Jie, Hei, Naihao, Dong, Bo, Su, Qing and Chen, Jing (2019) (Pro)renin receptor-mediated myocardial injury, apoptosis, and inflammatory response in rats with diabetic cardiomyopathy. Journal of Biological Chemistry, 294 . pp. 8218-8226. jbc.RA119.007648. doi:10.1074/jbc.RA119.007648 ISSN 0021-9258.
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WRAP-(Pro)renin-receptor-mediated-myocardial-injury-apoptosis-diabetic-Chen-.pdf - Accepted Version - Requires a PDF viewer. Download (1240Kb) | Preview |
Official URL: http://dx.doi.org/10.1074/jbc.RA119.007648
Abstract
Excessive activation of the renin-angiotensin system (RAS) in diabetic cardiomyopathy (DCM) provokes a series of structural and functional abnormalities, and causes ventricular remodeling and heart failure in diabetes. (Pro)renin receptor (PRR) is a component of the RAS and has been reported to be up-regulated in some cardiovascular diseases. Furthermore, PRR blockade in some cardiovascular diseases, such as myocardial infarction and hypertension, has been demonstrated to reverse their pathogenesis. However, there have been few studies about the function of PRR in the pathogenesis of DCM. In this study, we hypothesized that PRR is involved in the pathogenesis of DCM and mediates myocardial injury in DCM. To explore the role of PRR in DCM, we evaluated the effects of PRR overexpression and knockdown on the DCM phenotype in vivo and in vitro. The results show that PRR overexpression exacerbates myocardial injury and the inflammatory response in rats with DCM. Conversely, PRR knockdown alleviates myocardial fibrosis, apoptosis, and the inflammatory response, reversing the cardiac dysfunction in rats with DCM. In cell experiments, PRR overexpression also up-regulated the protein expression of collagen I and fibronectin, aggravated the inflammatory response, and increased the production of reactive oxygen species (ROS), while PRR knockdown had the opposite effect. Thus, PRR mediates myocardial injury, apoptosis, and the inflammatory response, likely through a PRR/extracellular signal-regulated kinase/ROS pathway.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | R Medicine > RC Internal medicine | |||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Myocardium -- Diseases, Diabetes -- Physiological aspects | |||||||||||||||
| Journal or Publication Title: | Journal of Biological Chemistry | |||||||||||||||
| Publisher: | American Society for Biochemistry and Molecular Biology | |||||||||||||||
| ISSN: | 0021-9258 | |||||||||||||||
| Official Date: | 17 May 2019 | |||||||||||||||
| Dates: |
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| Volume: | 294 | |||||||||||||||
| Page Range: | pp. 8218-8226 | |||||||||||||||
| Article Number: | jbc.RA119.007648 | |||||||||||||||
| DOI: | 10.1074/jbc.RA119.007648 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Reuse Statement (publisher, data, author rights): | This research was originally published in the Journal of Biological Chemistry.Dong, Xuefei, Yu, Shiran, Wang, Ying, Yang, Min, Xiong, Jie, Hei, Naihao, Dong, Bo, Su, Qing and Chen, Jing (2019) (Pro)renin receptor-mediated myocardial injury, apoptosis, and inflammatory response in rats with diabetic cardiomyopathy. Journal of Biological Chemistry . jbc.RA119.007648. doi:10.1074/jbc.RA119.007648 (In Press) © the American Society for Biochemistry and Molecular Biology or © the Author(s). | |||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
| Date of first compliant deposit: | 8 April 2019 | |||||||||||||||
| Date of first compliant Open Access: | 11 April 2019 | |||||||||||||||
| RIOXX Funder/Project Grant: |
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