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A study on the preparation of alkyne functional nanoparticles via RAFT emulsion polymerisation
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Gurnani, Pratik, Cook, Alexander B., Richardson, Robert A. E. and Perrier, Sébastien (2019) A study on the preparation of alkyne functional nanoparticles via RAFT emulsion polymerisation. Polymer Chemistry, 10 (12). pp. 1452-1459. doi:10.1039/C8PY01579A ISSN 1759-9954.
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Official URL: http://dx.doi.org/10.1039/C8PY01579A
Abstract
The multivalent presentation of functional groups on nanoparticle surfaces has long been exploited to attach biologically active moieties. The conventional chemistries typically used (amide, ester, disulfide) however, are non-selective and inefficient. The Huisgen azide alkyne [1,4] cycloaddition (CuAAC) ‘click’ reaction has paved the way for atom economic, and orthogonal conjugation chemistries, and is now widely used in nanoparticle science. In this work, alkyne functionalised nanoparticles were prepared, without lengthy post-nanoparticle synthesis modification procedures, exploiting RAFT emulsion polymerisations stabilised by functional macro-RAFT agents. Our results indicated that ester derived RAFT agents and addition of pendant charged groups are vital to retain colloidal stability and narrow molecular weight distributions. Finally the nanoparticles and model polymers were functionalised with an azido functional polymer and fluorescent dye, showing the surfaces were easily accessible for rapid and efficient post-polymerisation functionalisation.
Item Type: | Journal Article | ||||||||||||
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Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||||
Library of Congress Subject Headings (LCSH): | Fragmentation reactions, Nanoparticles, Addition polymerization, Emulsion polymerization | ||||||||||||
Journal or Publication Title: | Polymer Chemistry | ||||||||||||
Publisher: | Royal Society of Chemistry | ||||||||||||
ISSN: | 1759-9954 | ||||||||||||
Official Date: | 2019 | ||||||||||||
Dates: |
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Volume: | 10 | ||||||||||||
Number: | 12 | ||||||||||||
Page Range: | pp. 1452-1459 | ||||||||||||
DOI: | 10.1039/C8PY01579A | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
Date of first compliant deposit: | 9 April 2019 | ||||||||||||
Date of first compliant Open Access: | 12 February 2020 | ||||||||||||
RIOXX Funder/Project Grant: |
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