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Branched and dendritic polymer architectures : functional nanomaterials for therapeutic delivery
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Cook, Alexander B. and Perrier, Sébastien (2019) Branched and dendritic polymer architectures : functional nanomaterials for therapeutic delivery. Advanced Functional Materials . 1901001. doi:10.1002/adfm.201901001 ISSN 1616-3028.
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Official URL: https://doi.org/10.1002/adfm.201901001
Abstract
Barriers to therapeutic transport in biological systems can prevent accumulation of drugs at the intended site, thus limiting the therapeutic effect against various diseases. Advances in synthetic chemistry techniques have recently increased the accessibility of complex polymer architectures for drug delivery systems, including branched polymer architectures. This article first outlines drug delivery concepts, and then defines and illustrates all forms of branched polymers including highly branched polymers, hyperbranched polymers, dendrimers, and branched–linear hybrid polymers. Many new types of branched and dendritic polymers continue to be reported; however, there is often confusion about how to accurately describe these complex polymer architectures, particularly in the interdisciplinary field of nanomedicine where not all researchers have in‐depth polymer chemistry backgrounds. In this context, the present review describes and compares different branched polymer architectures and their application in therapeutic delivery in a simple and easy‐to‐understand way, with the aim of appealing to a multidisciplinary audience.
Item Type: | Journal Article | |||||||||||||||
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Subjects: | R Medicine > R Medicine (General) | |||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | |||||||||||||||
Library of Congress Subject Headings (LCSH): | Nanotechnology -- Research, Pharmaceutical biotechnology, Dendrimers, Drug delivery systems, Dendrimers in medicine | |||||||||||||||
Journal or Publication Title: | Advanced Functional Materials | |||||||||||||||
Publisher: | Wiley | |||||||||||||||
ISSN: | 1616-3028 | |||||||||||||||
Official Date: | 10 April 2019 | |||||||||||||||
Dates: |
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Article Number: | 1901001 | |||||||||||||||
DOI: | 10.1002/adfm.201901001 | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Reuse Statement (publisher, data, author rights): | "This is the peer reviewed version of the following article: Cook, A. B., Perrier, S., Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery. Adv. Funct. Mater. 2019, 1901001. https://doi.org/10.1002/adfm.201901001 which has been published in final form at https://doi.org/10.1002/adfm.201901001. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions." | |||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
Date of first compliant deposit: | 2 August 2019 | |||||||||||||||
Date of first compliant Open Access: | 10 April 2020 | |||||||||||||||
RIOXX Funder/Project Grant: |
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