Dunford, Joseph, Lutton, E. Josiah, Atia, Jolene, Blanks, Andrew M. and Van Den Berg, Hugo (2019) Computational physiology of uterine smooth muscle. Science Progress, 102 (2). pp. 103-126. doi:10.1177/0036850419850431

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Abstract

Pregnancy can be accompanied by serious health risks to mother and child, such as pre-eclampsia, premature birth, and postpartum haemorrhage. Understanding of the normal physiology of uterine function is essential to an improved management of such risks. Here we focus on the physiology of the smooth muscle fibres that make up the bulk of the uterine wall, and which generate the forceful contractions that accompany parturition. We survey computational methods that integrate mathematical modelling with data analysis and thereby aid the discovery of new therapeutic targets that, according to clinical needs, can be manipulated to either stop contractions or cause the uterine wall muscle to become active.

Item Type:	Journal Article
Subjects:	Q Science > QA Mathematics
Divisions:	Faculty of Science > Mathematics
Journal or Publication Title:	Science Progress
Publisher:	Science Reviews 2000 Ltd.
ISSN:	0036-8504
Official Date:	1 June 2019
Dates:	Date Event 1 June 2019 Published 20 May 2019 Available 22 April 2019 Accepted
Volume:	102
Number:	2
Page Range:	pp. 103-126
DOI:	10.1177/0036850419850431
Status:	Peer Reviewed
Publication Status:	Published
Publisher Statement:	This is an Accepted Manuscript of an article published by Science Reviews 2000 Ltd in Science Progress on 20/05/2019, available online: https://doi.org/10.1177/0036850419850431
Access rights to Published version:	Restricted or Subscription Access
Related URLs:	Publisher

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