Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

The effect of intravenous iron on erythropoiesis in older people with hip fracture

Tools
- Tools
+ Tools

Moppett, Iain, Rowlands, Matt, Mannings, Alexa, Marufu, Takawira, Sahota, Opinder and Yeung, Joyce (2019) The effect of intravenous iron on erythropoiesis in older people with hip fracture. Age and Ageing, 48 (5). pp. 751-755. doi:10.1093/ageing/afz049

[img]
Preview
PDF
WRAP-effect-intravenous-iron-erythropoiesis-older-people-hip-fracture-Yeong-2019.pdf - Accepted Version - Requires a PDF viewer.

Download (641Kb) | Preview
Official URL: https://doi.org/10.1093/ageing/afz049

Request Changes to record.

Abstract

Background

Anaemia following hip fracture is common and associated with worse outcomes. Intravenous iron is a potential non-transfusion treatment for this anaemia and has been found to reduce transfusion rates in previous observational studies. There is good evidence for its use in elective surgical populations.

Objective

To examine the impact of intravenous iron on erythropoiesis following hip fracture.

Design

Two-centre, assessor-blinded, randomised, controlled trial of patients with primary hip fracture and no contra-indications to intravenous iron.

Method

The intervention group received three doses of 200 mg iron sucrose over 30 min (Venofer, Vifor Pharma, Bagshot Park, UK) on three separate days. Primary outcome was reticulocyte count at day 7 after randomisation. Secondary outcomes included haemoglobin concentration, complications and discharge destination. Eighty participants were randomised.

Results

There was a statistically significantly greater absolute final reticulocyte count in the iron group (89.4 (78.9–101.3) × 109 cells l−1 (n = 39) vs. the control (72.2 (63.9–86.4)) × 109 cells l−1 (n = 41); P = 0.019; (mean (95% confidence intervals) of log-transformed data). There were no differences in final haemoglobin concentration (99.9 (95.7–104.2) vs. 102.0 (98.7–105.3) P = 0.454) or transfusion requirements in the first week (11 (28%) vs. 12 (29%); P = 0.899). Functional and safety outcomes were not different between the groups.

Conclusions

Although intravenous iron does stimulate erythropoiesis following hip fracture in older people, the effect is too small and too late to affect transfusion rates.

Trial Registry Numbers: ISRCTN:76424792; EuDRACT: 2011-003233-34.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit
Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Erythropoiesis, Erythropoietic failure, Anemia, Geriatrics, Blood -- Transfusion, Fractures in old age -- Treatment, Pelvic bones -- Fractures
Journal or Publication Title: Age and Ageing
Publisher: Oxford University Press
ISSN: 0002-0729
Official Date: 5 September 2019
Dates:
DateEvent
5 September 2019Published
25 May 2019Available
27 March 2019Accepted
Volume: 48
Number: 5
Page Range: pp. 751-755
DOI: 10.1093/ageing/afz049
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: This is a pre-copyedited, author-produced version of an article accepted for publication in Age and Ageing following peer review. The version of record I K Moppett, M Rowlands, A M Mannings, T C Marufu, O Sahota, J Yeung, The effect of intravenous iron on erythropoiesis in older people with hip fracture, Age and Ageing, , afz049, is available online at: https://doi.org/10.1093/ageing/afz049
Access rights to Published version: Restricted or Subscription Access
Description:

Free access

RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDAssociation of Anaesthetists of Great Britain and Irelandhttp://dx.doi.org/10.13039/501100007567
Related URLs:
  • Publisher

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us