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Myometrial transcriptional signatures of human parturition

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Stanfield, Zachary, Lai, Pei F., Lei, Kaiyu, Johnson, Mark R. D., Blanks, Andrew M., Romero, Roberto, Chance, Mark R., Mesiano, Sam and Koyutürk, Mehmet (2019) Myometrial transcriptional signatures of human parturition. Frontiers in Genetics, 10 . 185. doi:10.3389/fgene.2019.00185

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Official URL: https://doi.org/10.3389/fgene.2019.00185

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Abstract

The process of parturition involves the transformation of the quiescent myometrium (uterine smooth muscle) to the highly contractile laboring state. This is thought to be driven by changes in gene expression in myometrial cells. Despite the existence of multiple myometrial gene expression studies, the transcriptional programs that initiate labor are not known. Here, we integrated three transcriptome datasets, one novel (NCBI Gene Expression Ominibus: GSE80172) and two existing, to characterize the gene expression changes in myometrium associated with the onset of labor at term. Computational analyses including classification, singular value decomposition, pathway enrichment, and network inference were applied to individual and combined datasets. Outcomes across studies were integrated with multiple protein and pathway databases to build a myometrial parturition signaling network. A high-confidence (significant across all studies) set of 126 labor genes were identified and machine learning models exhibited high reproducibility between studies. Labor signatures included both known (interleukins, cytokines) and unknown (apoptosis, , cell proliferation/differentiation) pathways while cyclic AMP signaling and muscle relaxation were associated with non-labor. These signatures accurately classified and characterized the stages of labor. The data-derived parturition signaling networks provide new genes/signaling interactions to understand phenotype-specific processes and aid in future studies of parturition.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
Divisions: Faculty of Medicine > Warwick Medical School
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Human beings -- Parturition -- Genetics, Myometrium -- Genetics
Journal or Publication Title: Frontiers in Genetics
Publisher: Frontiers Research Foundation
ISSN: 1664-8021
Official Date: 1 April 2019
Dates:
DateEvent
1 April 2019Published
21 February 2019Accepted
Volume: 10
Article Number: 185
DOI: 10.3389/fgene.2019.00185
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: ** From PubMed via Jisc Publications Router ** History: received 19-10-2018; accepted 19-02-2019.
Access rights to Published version: Open Access
Description:

CORRECTION ARTICLE
Front. Genet. | doi: 10.3389/fgene.2019.00515
Authors list

RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDMarch of Dimes Prematurity Research Center Ohio Collaborativehttp://dx.doi.org/10.13039/100011636
UNSPECIFIEDEunice Kennedy Shriver National Institute of Child Health and Human Developmenthttp://dx.doi.org/10.13039/100009633
HD069818National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
U01-CA198941National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
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