The Library
Cell therapy for ischemic stroke : are differences in preclinical and clinical study design responsible for the translational loss of efficacy?
Tools
Cui, Li‐li, Golubczyk, Dominika, Tolppanen, Anna‐Maija, Boltze, Johannes and Jolkkonen, Jukka (2019) Cell therapy for ischemic stroke : are differences in preclinical and clinical study design responsible for the translational loss of efficacy? Annals of Neurology, 86 (1). pp. 5-16. doi:10.1002/ana.25493 ISSN 0364-5134.
|
PDF
WRAP-cell-therapy-ischemic-stroke-Boltze-2019.pdf - Accepted Version - Requires a PDF viewer. Download (1261Kb) | Preview |
|
|
PDF
WRAP-cell-therapy-ischemic-stroke-Boltze-2019-sup.pdf - Supplemental Material - Requires a PDF viewer. Download (220Kb) | Preview |
Official URL: http://dx.doi.org/10.1002/ana.25493
Abstract
Cell therapy is an attractive strategy for enhancing post‐stroke recovery. Different cell types and several treatment strategies have been successfully applied in animal models, but efficacy in stroke patients has not yet been confirmed. We hypothesize that the significant design differences between preclinical and clinical trials may account for this situation. Using a meta‐analysis approach and comparing preclinical with clinical trials, we reveal and discuss preliminary evidence for such design differences. While available datasets are not yet numerous enough to draw definitive conclusions, these findings may represent signposts on the route to efficacy by harmonizing preclinical and clinical study designs.
Item Type: | Journal Article | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subjects: | R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
|||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||
Library of Congress Subject Headings (LCSH): | Cellular therapy , Cerebral ischemia | |||||||||||||||
Journal or Publication Title: | Annals of Neurology | |||||||||||||||
Publisher: | Wiley | |||||||||||||||
ISSN: | 0364-5134 | |||||||||||||||
Official Date: | July 2019 | |||||||||||||||
Dates: |
|
|||||||||||||||
Volume: | 86 | |||||||||||||||
Number: | 1 | |||||||||||||||
Page Range: | pp. 5-16 | |||||||||||||||
DOI: | 10.1002/ana.25493 | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Reuse Statement (publisher, data, author rights): | This is the peer reviewed version of the following article: Cui, Li‐li, Golubczyk, Dominika, Tolppanen, Anna‐Maija, Boltze, Johannes and Jolkkonen, Jukka (2019) Cell therapy for ischemic stroke : are differences in preclinical and clinical study design responsible for the translational loss of efficacy? Annals of Neurology, which has been published in final form at: https://doi.org/10.1002/ana.25493 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
Date of first compliant deposit: | 22 May 2019 | |||||||||||||||
Date of first compliant Open Access: | 24 April 2020 | |||||||||||||||
RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year