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Right ventricular function after pulmonary artery banding : adaptive processes assessed by CMR and conductance catheter measurements in sheep
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Gufler, Hubert, Niefeldt, Sabine, Boltze, Johannes, Prietz, Stephanie, Klopsch, Christian, Wagner, Sabine, Vollmar, Brigitte and Yerebakan, Can (2019) Right ventricular function after pulmonary artery banding : adaptive processes assessed by CMR and conductance catheter measurements in sheep. Journal of Cardiovascular Translational Research, 12 (5). pp. 459-466. doi:10.1007/s12265-019-09881-6
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Official URL: http://dx.doi.org/10.1007/s12265-019-09881-6
Abstract
This experimental study describes the adaptive processes of the right ventricular (RV) myocardium after pulmonary artery banding (PAB) evaluated by cine cardiac magnetic resonance (CMR), phase-contrast CMR (PC-CMR), and conductance catheter. Seven sheep were subjected to CMR 3 months after PAB. Conductance catheter measurements were performed before and 3 months after PAB. Four nonoperated, healthy, age-matched animals served as controls. Higher RV masses (p < 0.01), elevated RV end-systolic volumes (p < 0.05), and lower RV ejection fraction (p < 0.01) were observed in the operated group. The time-to-peak pulmonary artery flow was longer in the banding group (p < 0.01). RV maximal pressure and RV end-diastolic pressure correlated with the time-to-peak flow in the pulmonary artery (r = − 0.70 and − 0.69, respectively). In summary, PAB caused RV hypertrophy, increased myocardial contractility, and decreased RV-EF and cardiac output. The time-to-peak pulmonary artery flow correlated with RV pressures.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||
| Library of Congress Subject Headings (LCSH): | Cardiovascular system --- Magnetic resonance imaging, Hemodynamics , Pulmonary hypertension | ||||||
| Journal or Publication Title: | Journal of Cardiovascular Translational Research | ||||||
| Publisher: | Springer | ||||||
| ISSN: | 1937-5387 | ||||||
| Official Date: | 7 March 2019 | ||||||
| Dates: |
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| Volume: | 12 | ||||||
| Number: | 5 | ||||||
| Page Range: | pp. 459-466 | ||||||
| DOI: | 10.1007/s12265-019-09881-6 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Publisher Statement: | This is a post-peer-review, pre-copyedit version of an article published in Journal of Cardiovascular Translational Research. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12265-019-09881-6 | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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