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Right ventricular function after pulmonary artery banding : adaptive processes assessed by CMR and conductance catheter measurements in sheep

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Gufler, Hubert, Niefeldt, Sabine, Boltze, Johannes, Prietz, Stephanie, Klopsch, Christian, Wagner, Sabine, Vollmar, Brigitte and Yerebakan, Can (2019) Right ventricular function after pulmonary artery banding : adaptive processes assessed by CMR and conductance catheter measurements in sheep. Journal of Cardiovascular Translational Research, 12 (5). pp. 459-466. doi:10.1007/s12265-019-09881-6

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Official URL: http://dx.doi.org/10.1007/s12265-019-09881-6

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Abstract

This experimental study describes the adaptive processes of the right ventricular (RV) myocardium after pulmonary artery banding (PAB) evaluated by cine cardiac magnetic resonance (CMR), phase-contrast CMR (PC-CMR), and conductance catheter. Seven sheep were subjected to CMR 3 months after PAB. Conductance catheter measurements were performed before and 3 months after PAB. Four nonoperated, healthy, age-matched animals served as controls. Higher RV masses (p < 0.01), elevated RV end-systolic volumes (p < 0.05), and lower RV ejection fraction (p < 0.01) were observed in the operated group. The time-to-peak pulmonary artery flow was longer in the banding group (p < 0.01). RV maximal pressure and RV end-diastolic pressure correlated with the time-to-peak flow in the pulmonary artery (r = − 0.70 and − 0.69, respectively). In summary, PAB caused RV hypertrophy, increased myocardial contractility, and decreased RV-EF and cardiac output. The time-to-peak pulmonary artery flow correlated with RV pressures.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Cardiovascular system --- Magnetic resonance imaging, Hemodynamics , Pulmonary hypertension
Journal or Publication Title: Journal of Cardiovascular Translational Research
Publisher: Springer
ISSN: 1937-5387
Official Date: 7 March 2019
Dates:
DateEvent
7 March 2019Available
26 February 2019Accepted
Volume: 12
Number: 5
Page Range: pp. 459-466
DOI: 10.1007/s12265-019-09881-6
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: This is a post-peer-review, pre-copyedit version of an article published in Journal of Cardiovascular Translational Research. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12265-019-09881-6
Access rights to Published version: Restricted or Subscription Access

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