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Skin-derived stem cells for wound treatment using cultured epidermal autografts : clinical applications and challenges
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Brockmann, Inga, Ehrenpfordt, Juliet, Sturmheit, Tabea, Brandenburger, Matthias, Kruse, Charli, Zille, Marietta, Rose, Dorothee and Boltze, Johannes (2018) Skin-derived stem cells for wound treatment using cultured epidermal autografts : clinical applications and challenges. Stem Cells International, 2018 . 4623615. doi:10.1155/2018/4623615
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WRAP-skin-derived-stem-cells-wound-treatment-cultured-epidermal-autograft-Boltze-2018.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1278Kb) | Preview |
Official URL: http://dx.doi.org/10.1155/2018/4623615
Abstract
The human skin fulfills important barrier, sensory, and immune functions—all of which contribute significantly to health and organism integrity. Widespread skin damage requires immediate treatment and coverage because massive skin loss fosters the invasion of pathogens, causes critical fluid loss, and may ultimately lead to death. Since the skin is a highly immunocompetent organ, autologous transplants are the only viable approach to permanently close a widespread skin wound. Despite the development of tissue-saving autologous transplantation techniques such as mesh and Meek grafts, treatment options for extensive skin damage remain severely limited. Yet, the skin is also a rich source of stem and progenitor cells. These cells promote wound healing under physiological conditions and are potential sources for tissue engineering approaches aiming to augment transplantable tissue by generating cultured epidermal autografts (CEAs). Here, we review autologous tissue engineering strategies as well as transplantation products based on skin-derived stem cells. We further provide an overview of clinical trial activities in the field and discuss relevant translational and clinical challenges associated with the use of these products.
| Item Type: | Journal Article | ||||||
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| Subjects: | R Medicine > R Medicine (General) R Medicine > RD Surgery |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| Library of Congress Subject Headings (LCSH): | Tissue engineering, Skin -- Wounds and injuries -- Treatment | ||||||
| Journal or Publication Title: | Stem Cells International | ||||||
| Publisher: | Hindawi | ||||||
| ISSN: | 1687-966X | ||||||
| Official Date: | 25 March 2018 | ||||||
| Dates: |
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| Volume: | 2018 | ||||||
| Number of Pages: | 9 | ||||||
| Article Number: | 4623615 | ||||||
| DOI: | 10.1155/2018/4623615 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access |
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