Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Dyslexia risk variant rs600753 is linked with dyslexia-specific differential allelic expression of DYX1C1

Tools
- Tools
+ Tools

Müller, Bent, Boltze, Johannes, Czepezauer, Ivonne, Hesse, Volker, Wilcke, Arndt and Kirsten, Holger (2018) Dyslexia risk variant rs600753 is linked with dyslexia-specific differential allelic expression of DYX1C1. Genetics and Molecular Biology, 41 (1). pp. 41-49. doi:10.1590/1678-4685-gmb-2017-0165 ISSN 1415-4757.

[img]
Preview
PDF
WRAP-dyslexia-risk variant-rs600753-linked-dyslexia-specific-differential-allelic-expression-DYX1C1-Boltze-2018.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (1690Kb) | Preview
Official URL: http://dx.doi.org/10.1590/1678-4685-gmb-2017-0165

Request Changes to record.

Abstract

An increasing number of genetic variants involved in dyslexia development were discovered during the last years, yet little is known about the molecular functional mechanisms of these SNPs. In this study we investigated whether dyslexia candidate SNPs have a direct, disease-specific effect on local expression levels of the assumed target gene by using a differential allelic expression assay. In total, 12 SNPs previously associated with dyslexia and related phenotypes were suitable for analysis. Transcripts corresponding to four SNPs were sufficiently expressed in 28 cell lines originating from controls and a family affected by dyslexia. We observed a significant effect of rs600753 on expression levels of DYX1C1 in forward and reverse sequencing approaches. The expression level of the rs600753 risk allele was increased in the respective seven cell lines from members of the dyslexia family which might be due to a disturbed transcription factor binding sites. When considering our results in the context of neuroanatomical dyslexia-specific findings, we speculate that this mechanism may be part of the pathomechanisms underlying the dyslexia-specific brain phenotype. Our results suggest that allele-specific DYX1C1 expression levels depend on genetic variants of rs600753 and contribute to dyslexia. However, these results are preliminary and need replication.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Dyslexia -- Genetic aspects
Journal or Publication Title: Genetics and Molecular Biology
Publisher: Sociedade Brasileira de Genética
ISSN: 1415-4757
Official Date: 19 February 2018
Dates:
DateEvent
19 February 2018Available
28 August 2017Accepted
Volume: 41
Number: 1
Page Range: pp. 41-49
DOI: 10.1590/1678-4685-gmb-2017-0165
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 23 May 2019
Date of first compliant Open Access: 23 May 2019
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDFraunhofer-Gesellschafthttp://dx.doi.org/10.13039/501100003185
UNSPECIFIEDMax-Planck-Gesellschafthttp://dx.doi.org/10.13039/501100004189

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us