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New antigenic regions of streptokinase are identified by affinity-directed mass spectrometry
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UNSPECIFIED (2001) New antigenic regions of streptokinase are identified by affinity-directed mass spectrometry. EUROPEAN JOURNAL OF BIOCHEMISTRY, 268 (19). pp. 5215-5221. ISSN 0014-2956.
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Abstract
Streptokinase (SK) is a bacterial protein used for the treatment of myocardial infarction, which is immunogenic in humans. Here we report the use of an affinity-directed MS approach to determine the minimal epitopes involved in the binding between SK and patient antibodies. Using this method we have identified two novel epitopes and mapped these to the minimal recognition regions formed by the amino acids D96-E99 and F323-D328. We have also located three previously identified antigenic regions and have now mapped them and shown that they can be defined more precisely as residues P4-L8, P171-P177 and K334-N338.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Journal or Publication Title: | EUROPEAN JOURNAL OF BIOCHEMISTRY | ||||
Publisher: | BLACKWELL SCIENCE LTD | ||||
ISSN: | 0014-2956 | ||||
Official Date: | October 2001 | ||||
Dates: |
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Volume: | 268 | ||||
Number: | 19 | ||||
Number of Pages: | 7 | ||||
Page Range: | pp. 5215-5221 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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