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Airway response to respiratory syncytial virus has incidental antibacterial effects
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Sand, Charles, Njunge, James, Mwongeli, Joyce, Mutunga, Martin, Chege, Timothy, Gicheru, Elijah, Gardiner, Elizabeth, Gwela, Agnes, Drysdale, Simon, Green, Christopher, Berkley, James, Nokes, D. James and Pollard, Andrew J. (2019) Airway response to respiratory syncytial virus has incidental antibacterial effects. Nature Communications, 10 (1). 2218. doi:10.1038/s41467-019-10222-z
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Official URL: https://doi.org/10.1038/s41467-019-10222-z
Abstract
RSV infection is typically associated with secondary bacterial infection. We hypothesise that the local airway immune response to RSV has incidental antibacterial effects. Using coordinated proteomics and metagenomics analysis we simultaneously analysed the microbiota and proteomes of the upper airway and determined direct antibacterial activity in airway secretions of RSV-infected children. Here, we report that the airway abundance of Streptococcus was higher in samples collected at the time of RSV infection compared with samples collected one month later. RSV infection is associated with neutrophil influx into the airway and degranulation and is marked by overexpression of proteins with known antibacterial activity including BPI, EPX, MPO and AZU1. Airway secretions of children infected with RSV, have significantly greater antibacterial activity compared to RSV-negative controls. This RSV-associated, neutrophil-mediated antibacterial response in the airway appears to act as a regulatory mechanism that modulates bacterial growth in the airways of RSV-infected children.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QR Microbiology R Medicine > RJ Pediatrics |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Respiratory syncytial virus, Bacterial diseases in children, Respiratory organs -- Obstructions -- Treatment | ||||||
| Journal or Publication Title: | Nature Communications | ||||||
| Publisher: | Nature Publishing Group | ||||||
| ISSN: | 2041-1723 | ||||||
| Official Date: | 17 May 2019 | ||||||
| Dates: |
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| Volume: | 10 | ||||||
| Number: | 1 | ||||||
| Article Number: | 2218 | ||||||
| DOI: | 10.1038/s41467-019-10222-z | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access | ||||||
| RIOXX Funder/Project Grant: |
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