UNSPECIFIED (2001) Expression of voltage-gated calcium channel subunits in rat dorsal root ganglion neurons. NEUROSCIENCE LETTERS, 311 (2). pp. 137-141. ISSN 0304-3940

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Abstract

In the present study, we have used in situ hybridisation to examine the distribution of calcium channel subunits in rat dorsal root ganglion (DRG) neurons. Within DRG neurons, the calcium channel alpha subunit mRNAs alpha (1A), alpha (1B), alpha (1C), alpha (1D), alpha (1E), alpha (1l) and alpha (1S) were readily detected in small (< 25 mum), medium (25-45 mum) and large (> 45 mum) diameter neurons. alpha (1F) was present at very low levels in these neurons whilst alpha (1G) was virtually undetectable. The calcium channel auxiliary subunits alpha (2)delta (1) and alpha (2)delta (2) showed a complementary pattern of distribution to that Of alpha (2)delta (3) in DRG neurons. alpha (2)delta (1) and alpha (2)delta (2) transcripts were expressed predominantly in small c-type sensory neurons and were present at lower levels in large A beta -type sensory neurons. In contrast, alpha (2)delta (3) mRNA was present in high quantities in the large-diameter cells but was expressed at lower levels in small-diameter neurons of the DRG. The present study provides an insight into the molecular profile of calcium channel alpha (1) and alpha (2)delta subunits in the neurons responsible for transmitting sensory information. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Journal or Publication Title:	NEUROSCIENCE LETTERS
Publisher:	ELSEVIER SCI IRELAND LTD
ISSN:	0304-3940
Date:	28 September 2001
Volume:	311
Number:	2
Number of Pages:	5
Page Range:	pp. 137-141
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/11698

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