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Lipase-catalyzed chemo- and enantioselective acetylation of 2-alkyl/aryl-3-hydroxypropiophenones
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UNSPECIFIED (2001) Lipase-catalyzed chemo- and enantioselective acetylation of 2-alkyl/aryl-3-hydroxypropiophenones. BIOORGANIC & MEDICINAL CHEMISTRY, 9 (10). pp. 2643-2652. ISSN 0968-0896
Full text not available from this repository.Abstract
The chemo- and enantioselective capabilities of porcine pancreatic lipase (PPL) in tetrahydrofuran, and Candida rugosa lipase (CRL) in diisopropyl ether have been investigated for the acetylation of racemic 2-alkyl/aryl-3-hydroxypropiophenones, which are important precursors in the synthesis of biologically active chromanones and isoflavanones. A highly chemoselective acetylation of primary hydroxy group in preference to phenolic hydroxy group leading to the formation of enantiomerically enriched monoacetates has been observed. (C) 2001 Elsevier Science Ltd. All rights reserved.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Journal or Publication Title: | BIOORGANIC & MEDICINAL CHEMISTRY |
| Publisher: | PERGAMON-ELSEVIER SCIENCE LTD |
| ISSN: | 0968-0896 |
| Date: | October 2001 |
| Volume: | 9 |
| Number: | 10 |
| Number of Pages: | 10 |
| Page Range: | pp. 2643-2652 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/11713 |
Data sourced from Thomson Reuters' Web of Knowledge
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