The Library
Low-dose dexamethasone augments the ovarian response to exogenous gonadotrophins leading to a reduction in cycle cancellation rate in a standard IVF programme
Tools
Tools
Tools
UNSPECIFIED (2001) Low-dose dexamethasone augments the ovarian response to exogenous gonadotrophins leading to a reduction in cycle cancellation rate in a standard IVF programme. HUMAN REPRODUCTION, 16 (9). pp. 1861-1865. ISSN 0268-1161
Full text not available from this repository.Abstract
BACKGROUND: Cancellation of assisted conception cycles because of poor ovarian response to gonadotrophins is a significant problem in assisted reproduction. Various adjuvant treatments have been suggested to improve responsiveness. This study reports on the potential benefits of low dose dexamethasone. METHODS: Patients <40 years of age were invited to participate in a twin centre prospective double blind randomized placebo controlled study. A total of 290 patients were recruited and computer randomized using sealed envelopes to receive either I mg dexamethasone (n = 145) or placebo tablets (n = 145) in addition to a standard long protocol gonadotrophin-releasing hormone analogue with gonadotrophin stimulation regime. RESULTS: A significantly lower cancellation rate for poor ovarian response was observed in the dexamethasone group compared with controls (2.8 versus 12.4% respectively, P < 0.002). Further comparisons between the dexamethasone group and controls were made of median fertilization rates (60 versus 61% respectively, NS), implantation rates (16.3 versus 11.6% respectively, NS) and pregnancy rate per cycle started (26.9 versus 17.2%, NS). The benefit was apparent in patients both with polycystic and normal ovaries. CONCLUSION: Low dose dexamethasone co-treatment reduces the incidence of poor ovarian response. It may increase clinical pregnancy rates and should be considered for inclusion in stimulation regimes to optimize ovarian response.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > RG Gynecology and obstetrics |
| Journal or Publication Title: | HUMAN REPRODUCTION |
| Publisher: | OXFORD UNIV PRESS |
| ISSN: | 0268-1161 |
| Date: | September 2001 |
| Volume: | 16 |
| Number: | 9 |
| Number of Pages: | 5 |
| Page Range: | pp. 1861-1865 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/11745 |
Data sourced from Thomson Reuters' Web of Knowledge
Actions (login required)
 |
View Item |
