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Breath analysis using eNose and ion mobility technology to diagnose inflammatory bowel disease - a pilot study
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Tiele, Akira, Wicaksono, Alfian, Kansara, Jiten, Arasaradnam, Ramesh P. and Covington, James A. (2019) Breath analysis using eNose and ion mobility technology to diagnose inflammatory bowel disease - a pilot study. Biosensors and Bioelectronics, 9 (2). 55. doi:10.3390/bios9020055
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Official URL: http://dx.doi.org/10.3390/bios9020055
Abstract
Early diagnosis of inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), remains a clinical challenge with current tests being invasive and costly. The analysis of volatile organic compounds (VOCs) in exhaled breath and biomarkers in stool (faecal calprotectin (FCP)) show increasing potential as non-invasive diagnostic tools. The aim of this pilot study is to evaluate the efficacy of breath analysis and determine if FCP can be used as an additional non-invasive parameter to supplement breath results, for the diagnosis of IBD. Thirty-nine subjects were recruited (14 CD, 16 UC, 9 controls). Breath samples were analysed using an in-house built electronic nose (Wolf eNose) and commercial gas chromatograph–ion mobility spectrometer (G.A.S. BreathSpec GC-IMS). Both technologies could consistently separate IBD and controls [AUC ± 95%, sensitivity, specificity], eNose: [0.81, 0.67, 0.89]; GC-IMS: [0.93, 0.87, 0.89]. Furthermore, we could separate CD from UC, eNose: [0.88, 0.71, 0.88]; GC-IMS: [0.71, 0.86, 0.62]. Including FCP did not improve distinction between CD vs. UC; eNose: [0.74, 1.00, 0.56], but rather, improved separation of CD vs. controls and UC vs. controls; eNose: [0.77, 0.55, 1.00] and [0.72, 0.89, 0.67] without FCP, [0.81, 0.73, 0.78] and [0.90, 1.00, 0.78] with FCP, respectively. These results confirm the utility of breath analysis to distinguish between IBD-related diagnostic groups. FCP does not add significant diagnostic value to breath analysis within this study.
| Item Type: | Journal Article | |||||||||
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| Subjects: | R Medicine > RC Internal medicine | |||||||||
| Divisions: | Faculty of Science > Engineering | |||||||||
| Library of Congress Subject Headings (LCSH): | Inflammatory bowel disease -- Diagnosis, Crohn's disease -- Diagnosis, Ulcerative colitis -- Diagnosis, Volatile organic compounds, Biochemical markers | |||||||||
| Journal or Publication Title: | Biosensors and Bioelectronics | |||||||||
| Publisher: | MDPI | |||||||||
| ISSN: | 0956-5663 | |||||||||
| Official Date: | 2019 | |||||||||
| Dates: |
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| Date of first compliant deposit: | 24 May 2019 | |||||||||
| Volume: | 9 | |||||||||
| Number: | 2 | |||||||||
| Article Number: | 55 | |||||||||
| DOI: | 10.3390/bios9020055 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access | |||||||||
| RIOXX Funder/Project Grant: |
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