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Breath analysis using eNose and ion mobility technology to diagnose inflammatory bowel disease - a pilot study

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Tiele, Akira, Wicaksono, Alfian, Kansara, Jiten, Arasaradnam, Ramesh P. and Covington, James A. (2019) Breath analysis using eNose and ion mobility technology to diagnose inflammatory bowel disease - a pilot study. Biosensors and Bioelectronics, 9 (2). 55. doi:10.3390/bios9020055

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Official URL: http://dx.doi.org/10.3390/bios9020055

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Abstract

Early diagnosis of inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), remains a clinical challenge with current tests being invasive and costly. The analysis of volatile organic compounds (VOCs) in exhaled breath and biomarkers in stool (faecal calprotectin (FCP)) show increasing potential as non-invasive diagnostic tools. The aim of this pilot study is to evaluate the efficacy of breath analysis and determine if FCP can be used as an additional non-invasive parameter to supplement breath results, for the diagnosis of IBD. Thirty-nine subjects were recruited (14 CD, 16 UC, 9 controls). Breath samples were analysed using an in-house built electronic nose (Wolf eNose) and commercial gas chromatograph–ion mobility spectrometer (G.A.S. BreathSpec GC-IMS). Both technologies could consistently separate IBD and controls [AUC ± 95%, sensitivity, specificity], eNose: [0.81, 0.67, 0.89]; GC-IMS: [0.93, 0.87, 0.89]. Furthermore, we could separate CD from UC, eNose: [0.88, 0.71, 0.88]; GC-IMS: [0.71, 0.86, 0.62]. Including FCP did not improve distinction between CD vs. UC; eNose: [0.74, 1.00, 0.56], but rather, improved separation of CD vs. controls and UC vs. controls; eNose: [0.77, 0.55, 1.00] and [0.72, 0.89, 0.67] without FCP, [0.81, 0.73, 0.78] and [0.90, 1.00, 0.78] with FCP, respectively. These results confirm the utility of breath analysis to distinguish between IBD-related diagnostic groups. FCP does not add significant diagnostic value to breath analysis within this study.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Science > Engineering
Library of Congress Subject Headings (LCSH): Inflammatory bowel disease -- Diagnosis, Crohn's disease -- Diagnosis, Ulcerative colitis -- Diagnosis, Volatile organic compounds, Biochemical markers
Journal or Publication Title: Biosensors and Bioelectronics
Publisher: MDPI
ISSN: 0956-5663
Official Date: 2019
Dates:
DateEvent
2019Published
12 April 2019Available
8 April 2019Accepted
Volume: 9
Number: 2
Article Number: 55
DOI: 10.3390/bios9020055
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDLembaga Pengelola Dana Pendidikan [Indonesian Education Fund Management Agency]UNSPECIFIED
UNSPECIFIEDIndonesia. Departemen Keuanganhttp://viaf.org/viaf/148921821

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