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Diazido platinum(IV) complexes for photoactivated anticancer chemotherapy

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Shi, Huayun, Imberti, Cinzia and Sadler, P. J. (2019) Diazido platinum(IV) complexes for photoactivated anticancer chemotherapy. Inorganic Chemistry Frontiers, 6 (7). pp. 1623-1638. doi:10.1039/c9qi00288j ISSN 2052-1553.

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Official URL: https://doi.org/10.1039/c9qi00288j

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Abstract

Diazido Pt(IV) complexes with a general formula [Pt(N3)2(L)(L′)(OR)(OR′)] are a new generation of anticancer prodrugs designed for use in photoactivated chemotherapy. The potencies of these complexes are affected by the cis/trans geometry configuration, the non-leaving ligand L/L′ and derivatisation of the axial ligand OR/OR′. Diazido Pt(IV) complexes exhibit high dark stability and promising photocytotoxicity circumventing cisplatin resistance. Upon irradiation, diazido Pt(IV) complexes release anticancer active Pt(II) species, azidyl radicals and ROS, which interact with biomolecules and therefore affect the cellular components and pathways. The conjugation of diazido Pt(IV) complexes with anticancer drugs or cancer-targeting vectors is an effective strategy to optimise the design of these photoactive prodrugs. Diazido Pt(IV) complexes represent a series of promising anticancer prodrugs owing to their novel mechanism of action which differs from that of classical cisplatin and its analogues.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
R Medicine > RC Internal medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Photochemotherapy , Cancer -- Photochemotherapy, Platinum -- Therapeutic use, Phototherapy
Journal or Publication Title: Inorganic Chemistry Frontiers
Publisher: RSC
ISSN: 2052-1553
Official Date: 1 July 2019
Dates:
DateEvent
1 July 2019Published
30 May 2019Available
26 April 2019Accepted
Volume: 6
Number: 7
Page Range: pp. 1623-1638
DOI: 10.1039/c9qi00288j
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 24 May 2019
Date of first compliant Open Access: 25 June 2019
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
G0701062[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
EP/G006792[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
EP/F034210/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
EP/P030572/1 [EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
247450[ERC] Horizon 2020 Framework Programmehttp://dx.doi.org/10.13039/100010661
Chancellor’s International PhD ScholarshipUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741
209173/Z/17/ZWellcome Trusthttp://dx.doi.org/10.13039/100010269
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