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Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps
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Ailloud, Florent, Didelot, Xavier, Woltemate, Sabrina, Pfaffinger, Gudrun, Overmann, Jörg, Bader, Ruth Christiane, Schulz, Christian, Malfertheiner, Peter and Suerbaum, Sebastian (2019) Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps. Nature Communications, 10 (1). 2273 . doi:10.1038/s41467-019-10050-1
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WRAP-within-host-evolution-Helicobacter-pylori-selective-sweeps-Didelot-2019.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1988Kb) | Preview |
Official URL: http://dx.doi.org/10.1038/s41467-019-10050-1
Abstract
The human pathogen Helicobacter pylori displays extensive genetic diversity. While H. pylori is known to evolve during infection, population dynamics inside the gastric environment have not been extensively investigated. Here we obtained gastric biopsies from multiple stomach regions of 16 H. pylori-infected adults, and analyze the genomes of 10 H. pylori isolates from each biopsy. Phylogenetic analyses suggest location-specific evolution and bacterial migration between gastric regions. Migration is significantly more frequent between the corpus and the fundus than with the antrum, suggesting that physiological differences between antral and oxyntic mucosa contribute to spatial partitioning of H. pylori populations. Associations between H. pylori gene polymorphisms and stomach niches suggest that chemotaxis, regulatory functions and outer membrane proteins contribute to specific adaptation to the antral and oxyntic mucosa. Moreover, we show that antibiotics can induce severe population bottlenecks and likely play a role in shaping the population structure of H. pylori.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QR Microbiology R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | |||||||||
| Library of Congress Subject Headings (LCSH): | Helicobacter pylori, Antibiotics | |||||||||
| Journal or Publication Title: | Nature Communications | |||||||||
| Publisher: | Nature Publishing Group | |||||||||
| ISSN: | 2041-1723 | |||||||||
| Official Date: | 22 May 2019 | |||||||||
| Dates: |
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| Date of first compliant deposit: | 28 May 2019 | |||||||||
| Volume: | 10 | |||||||||
| Number: | 1 | |||||||||
| Article Number: | 2273 | |||||||||
| DOI: | 10.1038/s41467-019-10050-1 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access | |||||||||
| RIOXX Funder/Project Grant: |
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