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Autograft or allograft for reconstruction of anterior cruciate ligament : a health economics perspective

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Mistry, Hema, Metcalfe, Andrew J., Colquitt, Jill, Loveman, Emma, Smith, Nick A., Royle, Pamela and Waugh, Norman (2019) Autograft or allograft for reconstruction of anterior cruciate ligament : a health economics perspective. Knee Surgery, Sports Traumatology, Arthroscopy, 27 (6). pp. 1782-1790. doi:10.1007/s00167-019-05436-z ISSN 0942-2056.

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Official URL: http://dx.doi.org/10.1007/s00167-019-05436-z

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Abstract

Purpose

To assess the clinical and cost-effectiveness of allografts versus autografts in the reconstruction of anterior cruciate ligaments.

Methods

Systematic review of comparative clinical effectiveness and cost-effectiveness analysis.

Results

Both autograft and allograft reconstruction are highly effective. Recent studies show little difference in failure rates between autografts and allografts (about 6% and 7%, respectively). In cost-effectiveness analysis, the price differential is the main factor, making autografts the first choice. However, there will be situations, particularly in revision ACL reconstruction, where an allograft may be preferred, or may be the only reasonable option available.

Conclusion

In ACL reconstruction, clinical results with autografts are as good as or slightly better than with allografts. Allografts cost more, indicating that autografts are more cost-effective and should usually be first choice.

Item Type: Journal Article
Subjects: R Medicine > RD Surgery
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET)
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Cruciate ligaments -- Surgery
Journal or Publication Title: Knee Surgery, Sports Traumatology, Arthroscopy
Publisher: Springer
ISSN: 0942-2056
Official Date: June 2019
Dates:
DateEvent
June 2019Published
14 March 2019Available
21 February 2019Accepted
Volume: 27
Number: 6
Page Range: pp. 1782-1790
DOI: 10.1007/s00167-019-05436-z
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 30 May 2019
Date of first compliant Open Access: 3 June 2019
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDEuropean Society of Sports Traumatology, Knee Surgery and Arthroscopyhttp://viaf.org/viaf/134546733

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