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Autograft or allograft for reconstruction of anterior cruciate ligament : a health economics perspective
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Mistry, Hema, Metcalfe, Andrew J., Colquitt, Jill, Loveman, Emma, Smith, Nick A., Royle, Pamela and Waugh, Norman (2019) Autograft or allograft for reconstruction of anterior cruciate ligament : a health economics perspective. Knee Surgery, Sports Traumatology, Arthroscopy, 27 (6). pp. 1782-1790. doi:10.1007/s00167-019-05436-z
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WRAP-autograft-allograft-reconstruction-anterior-cruciate-ligament-Mistry-2019.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1429Kb) | Preview |
Official URL: http://dx.doi.org/10.1007/s00167-019-05436-z
Abstract
Purpose
To assess the clinical and cost-effectiveness of allografts versus autografts in the reconstruction of anterior cruciate ligaments.
Methods
Systematic review of comparative clinical effectiveness and cost-effectiveness analysis.
Results
Both autograft and allograft reconstruction are highly effective. Recent studies show little difference in failure rates between autografts and allografts (about 6% and 7%, respectively). In cost-effectiveness analysis, the price differential is the main factor, making autografts the first choice. However, there will be situations, particularly in revision ACL reconstruction, where an allograft may be preferred, or may be the only reasonable option available.
Conclusion
In ACL reconstruction, clinical results with autografts are as good as or slightly better than with allografts. Allografts cost more, indicating that autografts are more cost-effective and should usually be first choice.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RD Surgery | ||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Cruciate ligaments -- Surgery | ||||||||
| Journal or Publication Title: | Knee Surgery, Sports Traumatology, Arthroscopy | ||||||||
| Publisher: | Springer | ||||||||
| ISSN: | 0942-2056 | ||||||||
| Official Date: | June 2019 | ||||||||
| Dates: |
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| Date of first compliant deposit: | 30 May 2019 | ||||||||
| Volume: | 27 | ||||||||
| Number: | 6 | ||||||||
| Page Range: | pp. 1782-1790 | ||||||||
| DOI: | 10.1007/s00167-019-05436-z | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| RIOXX Funder/Project Grant: |
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