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Understanding microbial community dynamics to improve optimal microbiome selection
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Wright, Robyn J., Gibson, Matthew I. and Christie-Oleza, Joseph Alexander (2019) Understanding microbial community dynamics to improve optimal microbiome selection. Microbiome, 7 (1). 85. doi:10.1186/s40168-019-0702-x ISSN 2049-2618.
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Official URL: http://dx.doi.org/10.1186/s40168-019-0702-x
Abstract
Background
Artificial selection of microbial communities that perform better at a desired process has seduced scientists for over a decade, but the method has not been systematically optimised nor the mechanisms behind its success, or failure, determined. Microbial communities are highly dynamic and, hence, go through distinct and rapid stages of community succession, but the consequent effect this may have on artificially selected communities is unknown.
Results
Using chitin as a case study, we successfully selected for microbial communities with enhanced chitinase activities but found that continuous optimisation of incubation times between selective transfers was of utmost importance. The analysis of the community composition over the entire selection process revealed fundamental aspects in microbial ecology: when incubation times between transfers were optimal, the system was dominated by Gammaproteobacteria (i.e. main bearers of chitinase enzymes and drivers of chitin degradation), before being succeeded by cheating, cross-feeding and grazing organisms.
Conclusions
The selection of microbiomes to enhance a desired process is widely used, though the success of artificially selecting microbial communities appears to require optimal incubation times in order to avoid the loss of the desired trait as a consequence of an inevitable community succession. A comprehensive understanding of microbial community dynamics will improve the success of future community selection studies.
Item Type: | Journal Article | ||||||||||||
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Subjects: | Q Science > QR Microbiology | ||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Proteobacteria, Microorganisms, Chitin | ||||||||||||
Journal or Publication Title: | Microbiome | ||||||||||||
Publisher: | BMC | ||||||||||||
ISSN: | 2049-2618 | ||||||||||||
Official Date: | 3 June 2019 | ||||||||||||
Dates: |
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Volume: | 7 | ||||||||||||
Number: | 1 | ||||||||||||
Article Number: | 85 | ||||||||||||
DOI: | 10.1186/s40168-019-0702-x | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
Copyright Holders: | © The Author(s). 2019 | ||||||||||||
Date of first compliant deposit: | 6 June 2019 | ||||||||||||
Date of first compliant Open Access: | 11 June 2019 | ||||||||||||
RIOXX Funder/Project Grant: |
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