UNSPECIFIED (2001) Measles virus strains circulating in Ethiopia in 1998-1999: Molecular characterisation using oral fluid samples and identification of a new genotype. JOURNAL OF MEDICAL VIROLOGY, 65 (2). pp. 373-380. ISSN 0146-6615

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Abstract

A measles outbreak in December 1998 in Bedelle (vaccine coverage < 40%) and two sporadic cases in Addis Ababa, Ethiopia, were investigated. Paired serum and oral fluid samples were collected 2-8 days after the onset of symptoms. A total of 53 of 55 outbreak cases and both sporadic cases were positive for serum measles virus-specific IgM. Oral fluid measles-specific IgM was positive in 71% of cases collected up to 5 days after onset and in 90% collected at 6-8 days. By contrast, 100% of oral fluid samples were positive for measles virus RNA by RT-PCR, suggesting that early collection of samples favoured the detection of measles virus RNA by RT-PCR. The measles virus strain in the outbreak was identified as genotype D4. One strain from a sporadic case was also genotype D4; the strain from the other sporadic case was assigned to clade D but was distinct. The degree of divergence from recognised clade D strains suggested that, together with three strains from the United Kingdom, it represents an additional genotype of clade D (GenBank accession numbers AF280800-280807). (C) 2001 Wiley-Liss, Inc.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR355 Virology
Journal or Publication Title:	JOURNAL OF MEDICAL VIROLOGY
Publisher:	WILEY-LISS
ISSN:	0146-6615
Date:	October 2001
Volume:	65
Number:	2
Number of Pages:	8
Page Range:	pp. 373-380
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/11821

Data sourced from Thomson Reuters' Web of Knowledge

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