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Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia
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Hockham, Carinna, Ekwattanakit, Supachai, Bhatt, Samir, Penman, Bridget S., Gupta, Sunetra, Viprakasit, Vip and Piel, Frédéric B (2019) Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia. eLife, 8 . e40580. doi:10.7554/eLife.40580
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Official URL: http://dx.doi.org/10.7554/eLife.40580
Abstract
Severe forms of α-thalassaemia, haemoglobin H disease and haemoglobin Bart’s hydrops fetalis, are an important public health concern in Southeast Asia. Yet information on the prevalence, genetic diversity and health burden of α-thalassaemia in the region remains limited. We compiled a geodatabase of α-thalassaemia prevalence and genetic diversity surveys and, using geostatistical modelling methods, generated the first continuous maps of α-thalassaemia mutations in Thailand and sub-national estimates of the number of newborns with severe forms in 2020. We also summarised the current evidence-base for α-thalassaemia prevalence and diversity for the region. We estimate that 3595 (95% credible interval 1,717–6,199) newborns will be born with severe α-thalassaemia in Thailand in 2020, which is considerably higher than previous estimates. Accurate, fine-scale epidemiological data are necessary to guide sustainable national and regional health policies for α-thalassaemia management. Our maps and newborn estimates are an important first step towards this aim.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||
| Journal or Publication Title: | eLife | ||||||
| Publisher: | eLife Sciences Publications Ltd. | ||||||
| ISSN: | 2050-084X | ||||||
| Official Date: | 23 May 2019 | ||||||
| Dates: |
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| Volume: | 8 | ||||||
| Article Number: | e40580 | ||||||
| DOI: | 10.7554/eLife.40580 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access |
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