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Mimicking the ice recrystallization activity of biological antifreezes. When is a new polymer “active”?
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Biggs, Caroline I., Stubbs, Christopher D., Graham, Ben, Fayter, Alice E. R., Hasan, Muhammad and Gibson, Matthew I. (2019) Mimicking the ice recrystallization activity of biological antifreezes. When is a new polymer “active”? Macromolecular Bioscience, 19 (7). 1900082. doi:10.1002/mabi.201900082 ISSN 1616-5187.
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WRAP-mimicking-ice-recrystallization-activity-biological-antifreezes-Gibson-2019.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2532Kb) | Preview |
Official URL: http://dx.doi.org/10.1002/mabi.201900082
Abstract
Antifreeze proteins and ice‐binding proteins have been discovered in a diverse range of extremophiles and have the ability to modulate the growth and formation of ice crystals. Considering the importance of cryoscience across transport, biomedicine, and climate science, there is significant interest in developing synthetic macromolecular mimics of antifreeze proteins, in particular to reproduce their property of ice recrystallization inhibition (IRI). This activity is a continuum rather than an “on/off” property and there may be multiple molecular mechanisms which give rise to differences in this observable property; the limiting concentrations for ice growth vary by more than a thousand between an antifreeze glycoprotein and poly(vinyl alcohol), for example. The aim of this article is to provide a concise comparison of a range of natural and synthetic materials that are known to have IRI, thus providing a guide to see if a new synthetic mimic is active or not, including emerging materials which are comparatively weak compared to antifreeze proteins, but may have technological importance. The link between activity and the mechanisms involving either ice binding or amphiphilicity is discussed and known materials assigned into classes based on this.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Macromolecular Bioscience | ||||||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||||||
| ISSN: | 1616-5187 | ||||||||
| Official Date: | July 2019 | ||||||||
| Dates: |
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| Volume: | 19 | ||||||||
| Number: | 7 | ||||||||
| Article Number: | 1900082 | ||||||||
| DOI: | 10.1002/mabi.201900082 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 2 July 2019 | ||||||||
| Date of first compliant Open Access: | 2 July 2019 |
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