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Translational models for vascular cognitive impairment : a review including larger species
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Hainsworth, Atticus H., Allan, Stuart M., Boltze, Johannes, Cunningham, Catriona, Farris, Chad, Head, Elizabeth, Ihara, Masafumi, Isaacs, Jeremy D., Kalaria, Raj N., Lesnik Oberstein, Saskia A. M. J., Moss, Mark B., Nitzsche, Björn, Rosenberg, Gary A., Rutten, Julie W., Salkovic-Petrisic, Melita and Troen, Aron M. (2017) Translational models for vascular cognitive impairment : a review including larger species. BMC Medicine, 15 (16). doi:10.1186/s12916-017-0793-9 ISSN 1741-7015.
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Official URL: http://dx.doi.org/10.1186/s12916-017-0793-9
Abstract
Background
Disease models are useful for prospective studies of pathology, identification of molecular and cellular mechanisms, pre-clinical testing of interventions, and validation of clinical biomarkers. Here, we review animal models relevant to vascular cognitive impairment (VCI). A synopsis of each model was initially presented by expert practitioners. Synopses were refined by the authors, and subsequently by the scientific committee of a recent conference (International Conference on Vascular Dementia 2015). Only peer-reviewed sources were cited.
Methods
We included models that mimic VCI-related brain lesions (white matter hypoperfusion injury, focal ischaemia, cerebral amyloid angiopathy) or reproduce VCI risk factors (old age, hypertension, hyperhomocysteinemia, high-salt/high-fat diet) or reproduce genetic causes of VCI (CADASIL-causing Notch3 mutations).
Conclusions
We concluded that (1) translational models may reflect a VCI-relevant pathological process, while not fully replicating a human disease spectrum; (2) rodent models of VCI are limited by paucity of white matter; and (3) further translational models, and improved cognitive testing instruments, are required.
| Item Type: | Journal Article | ||||||||||||||||||
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| Subjects: | R Medicine > RC Internal medicine | ||||||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Vascular dementia -- Animal models, Biochemical markers | ||||||||||||||||||
| Journal or Publication Title: | BMC Medicine | ||||||||||||||||||
| Publisher: | BioMed Central Ltd. | ||||||||||||||||||
| ISSN: | 1741-7015 | ||||||||||||||||||
| Official Date: | 25 January 2017 | ||||||||||||||||||
| Dates: |
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| Volume: | 15 | ||||||||||||||||||
| Number: | 16 | ||||||||||||||||||
| DOI: | 10.1186/s12916-017-0793-9 | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
| Date of first compliant deposit: | 12 June 2019 | ||||||||||||||||||
| Date of first compliant Open Access: | 14 June 2019 | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
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