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Iso-propyl stilbene : a life cycle signal?
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Hapeshi, Alexia, Benarroch, Jonatan Mimon, Clarke, David James and Waterfield, Nicholas R. (2019) Iso-propyl stilbene : a life cycle signal? Microbiology, 165 (5). pp. 516-526. doi:10.1099/mic.0.000790 ISSN 1350-0872.
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Official URL: http://dx.doi.org/10.1099/mic.0.000790
Abstract
Members of the Gram-negative bacterial genus Photorhabdus are all highly insect pathogenic and exist in an obligate symbiosis with the entomopathogenic nematode worm Heterorhabditis. All members of the genus produce the small-molecule 3,5-dihydroxy-4-isopropyl-trans-stilbene (IPS) as part of their secondary metabolism. IPS is a multi-potent compound that has antimicrobial, antifungal, immunomodulatory and anti-cancer activities and also plays an important role in symbiosis with the nematode. In this study we have examined the response of Photorhabdus itself to exogenous ectopic addition of IPS at physiologically relevant concentrations. We observed that the bacteria had a measureable phenotypic response, which included a decrease in bioluminescence and pigment production. This was reflected in changes in its transcriptomic response, in which we reveal a reduction in transcript levels of genes relating to many fundamental cellular processes, such as translation and oxidative phosphorylation. Our observations suggest that IPS plays an important role in the biology of Photorhabdus bacteria, fulfilling roles in quorum sensing, antibiotic-competition advantage and maintenance of the symbiotic developmental cycle.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Journal or Publication Title: | Microbiology | ||||||||
Publisher: | Society for General Microbiology | ||||||||
ISSN: | 1350-0872 | ||||||||
Official Date: | May 2019 | ||||||||
Dates: |
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Volume: | 165 | ||||||||
Number: | 5 | ||||||||
Page Range: | pp. 516-526 | ||||||||
DOI: | 10.1099/mic.0.000790 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Open Access Version: |
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