Rose, Dorothee, Schmidt, Annette, Brandenburger, Matthias, Sturmheit, Tabea, Zille, Marietta and Boltze, Johannes (2018) Sulfur mustard skin lesions : a systematic review on pathomechanisms, treatment options and future research directions. Toxicology letters, 293 . pp. 82-90. doi:10.1016/j.toxlet.2017.11.039 ISSN 1879-3169.

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Abstract

Sulfur mustard (SM) is a chemical warfare, which has been used for one hundred years. However, its exact pathomechanisms are still incompletely understood and there is no specific therapy available so far. In this systematic review, studies published between January 2000 and July 2017 involving pathomechanisms and experimental treatments of SM-induced skin lesions were analyzed to summarize current knowledge on SM pathology, to provide an overview on novel treatment options, and to identify promising targets for future research to more effectively counter SM effects. We suggest that future studies should focus on (I) systemic effects of SM intoxication due to its distribution throughout the body, (II) removal of SM depots that continuously release active compound contributing to chronic skin damage, and (III) therapeutic options that counteract the pleiotropic effects of SM.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Journal or Publication Title:	Toxicology letters
Publisher:	Elsevier
ISSN:	1879-3169
Official Date:	1 September 2018
Dates:	Date Event 1 September 2018 Published 2 December 2017 Available 28 November 2017 Accepted
Volume:	293
Page Range:	pp. 82-90
DOI:	10.1016/j.toxlet.2017.11.039
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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