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Impaired structural connectivity between dorsal attention network and pulvinar mediates the impact of premature birth on adult visual–spatial abilities
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Berndt, Maria, Bäuml, Josef G., Menegaux, Aurore, Meng, Chun, Daamen, Marcel, Baumann, Nicole, Zimmer, Claus, Boecker, Henning, Bartmann, Peter, Wolke, Dieter and Sorg, Christian (2019) Impaired structural connectivity between dorsal attention network and pulvinar mediates the impact of premature birth on adult visual–spatial abilities. Human Brain Mapping, 40 (14). pp. 4058-4071. doi:10.1002/hbm.24685 ISSN 1065-9471.
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WRAP-impaired-structural-connectivity-between-dorsal-attention-network-pulvinar-mediates-impact-Wolke-2019.pdf - Accepted Version - Requires a PDF viewer. Download (1428Kb) | Preview |
Official URL: http://dx.doi.org/10.1002/hbm.24685
Abstract
The dorsal attention network (DAN), including frontal eye fields and posterior parietal cortices, and its link with the posterior thalamus, contribute to visual–spatial abilities. Very premature birth impairs both visual–spatial abilities and cortico‐thalamic structural connectivity. We hypothesized that impaired structural DAN‐pulvinar connectivity mediates the effect of very premature birth on adult visual–spatial abilities. Seventy very premature (median age 26.6 years) and 57 mature born adults (median age 26.6 years) were assessed with cognitive tests and diffusion tensor imaging. Perceptual organization (PO) index of the Wechsler Adult Intelligence Scale‐III was used as a proxy for visual–spatial abilities, and connection probability maps in the thalamus, derived from probabilistic tractography from the DAN, were used as a proxy for DAN‐thalamic connectivity. Premature born adults showed decreases in both PO‐index and connection probability from DAN into the pulvinar, with both changes being positively correlated. Moreover, path analysis revealed that DAN‐pulvinar connectivity mediates the relationship between very premature birth and PO‐index. Results provide evidence for long‐term effects of very premature birth on structural DAN‐pulvinar connectivity, mediating the effect of prematurity on adult visual–spatial impairments. Data suggest DAN‐pulvinar connectivity as a specific target of prognostic and diagnostic procedures for visual–spatial abilities after premature birth.
Item Type: | Journal Article | |||||||||
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Subjects: | R Medicine > RJ Pediatrics | |||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Premature infants, Cerebellum, Cognition | |||||||||
Journal or Publication Title: | Human Brain Mapping | |||||||||
Publisher: | John Wiley and Sons | |||||||||
ISSN: | 1065-9471 | |||||||||
Official Date: | 1 October 2019 | |||||||||
Dates: |
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Volume: | 40 | |||||||||
Number: | 14 | |||||||||
Page Range: | pp. 4058-4071 | |||||||||
DOI: | 10.1002/hbm.24685 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Reuse Statement (publisher, data, author rights): | This is the peer reviewed version of the following article: Berndt, M, Bäuml, JG, Menegaux, A, et al. Impaired structural connectivity between dorsal attention network and pulvinar mediates the impact of premature birth on adult visual–spatial abilities. Hum Brain Mapp. 2019; 1– 14. https://doi.org/10.1002/hbm.24685, which has been published in final form at https://doi.org/10.1002/hbm.24685. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||
Date of first compliant deposit: | 14 June 2019 | |||||||||
Date of first compliant Open Access: | 9 June 2020 | |||||||||
RIOXX Funder/Project Grant: |
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