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Exploring the impact of analysis software on task fMRI results

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Bowring, Alexander, Maumet, Camille and Nichols, Thomas E. (2019) Exploring the impact of analysis software on task fMRI results. Human Brain Mapping, 40 (11). pp. 3362-3384. doi:10.1002/hbm.24603 ISSN 1065-9471.

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Official URL: http://dx.doi.org/10.1002/hbm.24603

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Abstract

A wealth of analysis tools are available to fMRI researchers in order to extract patterns of task variation and, ultimately, understand cognitive function. However, this “methodological plurality” comes with a drawback. While conceptually similar, two different analysis pipelines applied on the same dataset may not produce the same scientific results. Differences in methods, implementations across software, and even operating systems or software versions all contribute to this variability. Consequently, attention in the field has recently been directed to reproducibility and data sharing. In this work, our goal is to understand how choice of software package impacts on analysis results. We use publicly shared data from three published task fMRI neuroimaging studies, reanalyzing each study using the three main neuroimaging software packages, AFNI, FSL, and SPM, using parametric and nonparametric inference. We obtain all information on how to process, analyse, and model each dataset from the publications. We make quantitative and qualitative comparisons between our replications to gauge the scale of variability in our results and assess the fundamental differences between each software package. Qualitatively we find similarities between packages, backed up by Neurosynth association analyses that correlate similar words and phrases to all three software package's unthresholded results for each of the studies we reanalyse. However, we also discover marked differences, such as Dice similarity coefficients ranging from 0.000 to 0.684 in comparisons of thresholded statistic maps between software. We discuss the challenges involved in trying to reanalyse the published studies, and highlight our efforts to make this research reproducible.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Science > Statistics
Journal or Publication Title: Human Brain Mapping
Publisher: John Wiley and Sons
ISSN: 1065-9471
Official Date: 1 August 2019
Dates:
DateEvent
1 August 2019Published
2 May 2019Available
8 April 2019Accepted
Volume: 40
Number: 11
Page Range: pp. 3362-3384
DOI: 10.1002/hbm.24603
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)

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