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The population structure of Pseudomonas aeruginosa is characterized by genetic isolation of exoU+ and exoS+ lineages

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Ozer, Egon A., Nnah, Ekpeno, Didelot, Xavier, Whitaker, Rachel J. and Hauser, Alan R. (2019) The population structure of Pseudomonas aeruginosa is characterized by genetic isolation of exoU+ and exoS+ lineages. Genome Biology and Evolution, 11 (1). pp. 1780-1796. doi:10.1093/gbe/evz119

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Official URL: https://doi.org/10.1093/gbe/evz119

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Abstract

The diversification of microbial populations may be driven by many factors including adaptation to distinct ecological niches and barriers to recombination. We examined the population structure of the bacterial pathogen Pseudomonas aeruginosa by analyzing whole-genome sequences of 739 isolates from diverse sources. We confirmed that the population structure of P. aeruginosa consists of two major groups (referred to as Groups A and B) and at least two minor groups (Groups C1 and C2). Evidence for frequent intra-group but limited inter-group recombination in the core genome was observed, consistent with sexual isolation of the groups. Likewise, accessory genome analysis demonstrated more gene flow within Groups A and B than between these groups, and a few accessory genomic elements were nearly specific to one or the other group. In particular, the exoS gene was highly over-represented in Group A compared to Group B isolates (99.4% vs. 1.1%) and the exoU gene was highly over-represented in Group B compared to Group A isolates (95.2% vs. 1.8%). The exoS and exoU genes encode effector proteins secreted by the P. aeruginosa type III secretion system. Together these results suggest that the major P. aeruginosa groups defined in part by the exoS and exoU genes are divergent from each other, and that these groups are genetically isolated and may be ecologically distinct. Although both groups were globally distributed and caused human infections, certain groups predominated in some clinical contexts.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology
Divisions: Faculty of Science > Life Sciences (2010- )
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Pseudomonas aeruginosa, Microbial populations, Population biology, Genetic recombination
Journal or Publication Title: Genome Biology and Evolution
Publisher: Oxford University Press (OUP)
ISSN: 1759-6653
Official Date: January 2019
Dates:
DateEvent
January 2019Published
7 June 2019Available
5 June 2019Accepted
Volume: 11
Number: 1
Page Range: pp. 1780-1796
DOI: 10.1093/gbe/evz119
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
K24AI104831National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
R01 AI053674National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
R01 AI118257National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
U19 AI135964National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
WHITAK16P0Cystic Fibrosis Foundationhttp://dx.doi.org/10.13039/100000897
MRSG-13-220-01American Cancer Societyhttp://dx.doi.org/10.13039/100000048
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