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Novel lipase-catalysed enantioselective deacetylation of (+/-)-5-acetoxy-3-(4-fluorophenyl)-2-phenylisoxazolidine
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UNSPECIFIED. (2001) Novel lipase-catalysed enantioselective deacetylation of (+/-)-5-acetoxy-3-(4-fluorophenyl)-2-phenylisoxazolidine. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 11 (16). pp. 2117-2121. ISSN 0960-894X
Full text not available from this repository.Abstract
(+/-)-5-Acetoxy-3-(4-fluorophenyl)-2-phenylisoxazolidine has been synthesised by a highly diastereoselective [3+2] cycloaddition reaction between alpha-(4-fluorophenyl)-N-phenylnitrone and vinyl acetate in good yield. Candida rugosa lipase catalyses the deacetylation of this (+/-)-5-acetoxyisoxazolidine in a highly enantioselective fashion in diisopropyl ether containing n-butanol affording (-)-5-acetoxy-3-(4-fluorophenyl)-2-phenylisoxazolidine in 43% yield and > 99% cc. (C) 2001 Elsevier Science Ltd. All rights reserved.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Journal or Publication Title: | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS |
| Publisher: | PERGAMON-ELSEVIER SCIENCE LTD |
| ISSN: | 0960-894X |
| Date: | 20 August 2001 |
| Volume: | 11 |
| Number: | 16 |
| Number of Pages: | 5 |
| Page Range: | pp. 2117-2121 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/11893 |
Data sourced from Thomson Reuters' Web of Knowledge
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