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Towards personalised molecular feedback for weight loss
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Tejpal, Shilpa, Sanghera, Narinder, Manoharan, Vijayalaxmi, Planas-Iglesias, Joan, Myler, Kate and Klein-Seetharaman, Judith (2019) Towards personalised molecular feedback for weight loss. BMC Obesity, 6 (1). 20. doi:10.1186/s40608-019-0237-5 ISSN 2052-9538.
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Official URL: http://dx.doi.org/10.1186/s40608-019-0237-5
Abstract
Background
Numerous diets, apps and websites help guide and monitor dietary behaviour with the goal of losing weight, yet dieting success is highly dependent on personal preferences and circumstances. To enable a more quantitative approach to dieting, we developed an integrated platform that allows tracking of life-style information alongside molecular biofeedback measurements (lactate and insulin).
Methods
To facilitate weight loss, participants (≥18 years) omitted one main meal from the usual three-meal routine. Daily caloric intake was restricted to ~1200KCal with one optional snack ≤250KCal. A mobile health platform (personalhealth.warwick.ac.uk) was developed and used to maintain diaries of food intake, weight, urine collection and volume. A survey was conducted to understand participants’ willingness to collect samples, motivation for taking part in the study and reasons for dropout.
Results
Meal skipping resulted in weight loss after a 24 h period in contrast to 3-meal control days regardless of the meal that was skipped, breakfast, lunch or dinner (p < 0.001). Common reasons for engagement were interest in losing weight and personal metabolic profile. Total insulin and lactate values varied significantly between healthy and obese individuals at p = 0.01 and 0.05 respectively.
Conclusion
In a proof of concept study with a meal-skipping diet, we show that insulin and lactate values in urine correlate with weight loss, making these molecules potential candidates for quantitative feedback on food intake behaviour to people dieting.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) |
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| Journal or Publication Title: | BMC Obesity | ||||||||
| Publisher: | BioMed Central Ltd. | ||||||||
| ISSN: | 2052-9538 | ||||||||
| Official Date: | 6 May 2019 | ||||||||
| Dates: |
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| Volume: | 6 | ||||||||
| Number: | 1 | ||||||||
| Article Number: | 20 | ||||||||
| DOI: | 10.1186/s40608-019-0237-5 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 28 August 2019 | ||||||||
| Date of first compliant Open Access: | 28 August 2019 | ||||||||
| RIOXX Funder/Project Grant: |
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