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Concise review : MSC adhesion cascade-insights into homing and transendothelial migration

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Nitzsche, Franziska, Müller, Claudia, Lukomska, Barbara, Jolkkonen, Jukka, Deten, Alexander and Boltze, Johannes (2017) Concise review : MSC adhesion cascade-insights into homing and transendothelial migration. Stem Cells, 35 (6). pp. 1446-1460. doi:10.1002/stem.2614

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Official URL: http://dx.doi.org/10.1002/stem.2614

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Abstract

Mesenchymal stem cells (MSCs) are promising candidates for adult cell therapies in regenerative medicine. To fully exert their potential, efficient homing and migration toward lesion sites play an important role. Local transplantation deposits MSC in spatial proximity to the lesion, but often requires invasive procedures. Systemic administration routes are favored, but require the targeted extravasation of the circulating MSC at the site of injury. Transplanted MSC can indeed leave the blood flow and transmigrate through the endothelial barrier, and reach the lesion site. However, the underlying processes are not completely dissolved yet. Recent in vitro and in vivo research identified some key molecules scattered light on the extravasation mechanism. This review provides a detailed overview over the current knowledge of MSC transendothelial migration. We use the leukocyte extravasation process as a role model to build a comprehensive concept of MSC egress mechanisms from the blood stream and identified relevant similarities as well as important differences between the extravasation mechanisms.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Q Science > QP Physiology
Q Science > QR Microbiology
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Cell adhesion molecules, Cell migration , Chemokines , Chemokines -- Receptors , Integrins, Mesenchymal stem cells , Stem cells, Leucocytes
Journal or Publication Title: Stem Cells
Publisher: AlphaMed Press, Inc.
ISSN: 1066-5099
Official Date: 18 March 2017
Dates:
DateEvent
18 March 2017Published
23 February 2017Accepted
Volume: 35
Number: 6
Page Range: pp. 1446-1460
DOI: 10.1002/stem.2614
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access

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