Long-term stability of diverse immunological memory
UNSPECIFIED. (2001) Long-term stability of diverse immunological memory. JOURNAL OF THEORETICAL BIOLOGY, 211 (4). pp. 393-402. ISSN 0022-5193Full text not available from this repository.
Mathematical modelling is used to examine the effects of T cell apoptosis and memory differentiation dynamics on memory retention (memory stability). Apoptosis by cytokine deprivation induced death, and competition for survival signals are incorporated. Our models indicate that such population dependent processes are essential for the preservation of specific memory to previously encountered pathogens. Memory stability and vaccination properties improve significantly when population dependent mechanisms are present. These mechanisms work synergistically together to further improve memory characteristics. Our models emphasize the role of competitive cellular mechanisms in regulating repertoire structure and characteristics. (C) 2001 Academic Press.
|Item Type:||Journal Article|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Journal or Publication Title:||JOURNAL OF THEORETICAL BIOLOGY|
|Publisher:||ACADEMIC PRESS LTD|
|Date:||21 August 2001|
|Number of Pages:||10|
|Page Range:||pp. 393-402|
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