The Library
Pushing arterial-venous plasma biomarkers to new heights : a model for personalised redox metabolomics?
Tools
Tools
Tools
Cumpstey, Andrew F., Minnion, Magdalena, Fernandez, Bernadette O., Mikus-Lelinska, Monika, Mitchell, Kay, Martin, Daniel S., Grocott, Michael P. W. and Feelisch, Martin (2019) Pushing arterial-venous plasma biomarkers to new heights : a model for personalised redox metabolomics? Redox Biology, 21 . 101113. doi:10.1016/j.redox.2019.101113 ISSN 2213-2317.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.redox.2019.101113
Abstract
The chemical and functional interactions between Reactive Oxygen (ROS), Nitrogen (RNS) and Sulfur (RSS) species allow organisms to detect and respond to metabolic and environmental stressors, such as exercise and altitude exposure. Whether redox markers and constituents of this ‘Reactive Species Interactome’ (RSI) differ in concentration between arterial and venous blood is unknown. We hypothesised that such measurements may provide useful insight into metabolic/redox regulation at the whole-body level and would be consistent between individuals exposed to identical challenges. An exploratory study was performed during the Xtreme Alps expedition in 2010 in which four healthy individuals (2 male, 2 female) underwent paired arterial and central venous blood sampling before, during and after performance of a constant-work-rate cardiopulmonary exercise test, at sea level and again at 4559 m. Unexpectedly, plasma total free thiol and free cysteine concentrations remained substantially elevated at altitude throughout exercise with minimal arteriovenous gradients. Free sulfide concentrations changed only modestly upon combined altitude/exercise stress, whereas bound sulfide levels were lower at altitude than sea-level. No consistent signal indicative of the expected increased oxidative stress and nitrate→nitrite→NO reduction was observed with 4-hydroxynonenal, isoprostanes, nitrate, nitrite, nitroso species and cylic guanosine monophosphate. However, the observed arteriovenous concentration differences revealed a dynamic pattern of response that was unique to each participant. This novel redox metabolomic approach of obtaining quantifiable ‘metabolic signatures’ to a defined physiological challenge could potentially offer new avenues for personalised medicine.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
| Journal or Publication Title: | Redox Biology | ||||||||
| Publisher: | Elsevier | ||||||||
| ISSN: | 2213-2317 | ||||||||
| Official Date: | February 2019 | ||||||||
| Dates: |
|
||||||||
| Volume: | 21 | ||||||||
| Article Number: | 101113 | ||||||||
| DOI: | 10.1016/j.redox.2019.101113 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Contributors: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
