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The current state of cell therapies for cerebrovascular diseases
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Jolkkonen, Jukka, Mendez-Otero, Rosalia, de Freitas, Gabriel Rodriguez, Boltze, Johannes and Rosado-de-Castro, Paulo Henrique (2016) The current state of cell therapies for cerebrovascular diseases. Stem Cells International, 2016 . pp. 1-2. 5215824. doi:10.1155/2016/5215824 ISSN 1687-966X.
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Official URL: http://dx.doi.org/10.1155/2016/5215824
Abstract
Although cerebrovascular diseases are among the leading causes of health burden in the world, presently existing therapies have narrow capabilities in the treatment of such ailments [1, 2]. Cell therapies were originally used in hematological disorders and are currently being investigated as potential treatments for diverse conditions [3, 4]. Several preclinical reports have indicated that cell transplantation may generate beneficial functional and structural outcomes in stroke animals, even though the underlying mechanisms for such effects are still the subject of intensive research [5–7]. In the clinical setting, preliminary studies have been published indicating a good safety profile of systemic cell therapies, but additional trials are needed to assess the possible feasibility and efficacy of cell transplantation in cerebrovascular patients [5, 8, 9]. Furthermore, there are numerous obstacles to be tackled in order to thoroughly translate results from animal studies to patients [5, 8, 9].
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| Journal or Publication Title: | Stem Cells International | ||||||
| Publisher: | Hindawi | ||||||
| ISSN: | 1687-966X | ||||||
| Official Date: | 2016 | ||||||
| Dates: |
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| Volume: | 2016 | ||||||
| Page Range: | pp. 1-2 | ||||||
| Article Number: | 5215824 | ||||||
| DOI: | 10.1155/2016/5215824 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) |
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