Werner, Peter, Saur, Dorothee, Zeisig, Vilia, Ettrich, Barbara, Patt, Marianne, Sattler, Bernhard, Jochimsen, Thies, Lobsien, Donald, Meyer, Philipp M, Bergh, Florian Then, Dreyer, Antje, Boltze, Johannes, Classen, Joseph, Fritzsch, Dominik, Hoffmann, Karl-Titus, Sabri, Osama and Barthel, Henryk (2015) Simultaneous PET/Mri in stroke : a case series. Journal of Cerebral Blood Flow & Metabolism, 35 (9). pp. 1421-1425. doi:10.1038/jcbfm.2015.158 ISSN 0271-678X.

Research output not available from this repository.

Request-a-Copy directly from author or use local Library Get it For Me service.

Request Changes to record.

Abstract

Prospective studies on magnetic resonance imaging (MRI)-guided systemic thrombolysis 44.5 hours after stroke onset did not reach their primary end points. It was discussed and observed in post hoc data re-assessment that this was partly because of limited MRI accuracy to measure critical hypoperfusion. We report the first cases of simultaneous [15O]H2O-positron emission tomography (PET)/MRI in stroke patients and an ovine model. Discrepancies between simultaneously obtained PET and MRI readouts were observed that might explain the above current limitations of stroke MRI. By offering highly complementary information, [15O]H2O-PET/MRI might help to identify critically hypoperfused tissue resulting in an improved patient stratification in thrombolysis trials.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Journal or Publication Title:	Journal of Cerebral Blood Flow & Metabolism
Publisher:	Nature Publishing Group
ISSN:	0271-678X
Official Date:	September 2015
Dates:	Date Event September 2015 Published July 2015 Available
Volume:	35
Number:	9
Page Range:	pp. 1421-1425
DOI:	10.1038/jcbfm.2015.158
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

Request changes or add full text files to a record

Repository staff actions (login required)

View Item