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Metformin and dapagliflozin effects on epicardial adipose tissue area in prediabetes and type 2 diabetes patients : MRI evaluation studies
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Al-Talabany, S., Weir-McCall, J., Mohan, Mohapradeep, Singh, J., Mordi, I., Gandy, S., Khan, F., Choy, A.M., Houston, G., Pearson, E., George, J., Struthers, A. and Lang, C. (2018) Metformin and dapagliflozin effects on epicardial adipose tissue area in prediabetes and type 2 diabetes patients : MRI evaluation studies. In: World Congress of Cardiology & Cardiovascular Health 2018. Published in: Global Heart, 13 (4). p. 392. ISSN 2211-8179. doi:10.1016/j.gheart.2018.09.060
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Official URL: http://dx.doi.org/10.1016/j.gheart.2018.09.060
Abstract
397421) (n=56 patients ,mean age 67 ± 7 y; mean BMI 32.5± 5.3 kg/m2) with chronic heart failure and type 2 diabetes who received either dapagliflozin (10mg/day) or placebo for 12 months respectively.
Results:
Metformin treatment in the METREMODEL trial reduced body weight significantly by 4.2kgs (p=0.001).but did not reduce EAT area (metformin -0.1 ± 3.8 cm2 vs. placebo -0.5 ± 2.9 cm2 p= 0.7). In the REFORM trial, dapagliflozin reduced body weight significantly by -1.9 kg (p= 0.054) with no significant reduction in EAT area (dapagliflozin -1.00 ± 3.6 cm2 vs. placebo -0.7 ± 3.1 p=0.8).
Conclusion:
In prediabetes and type 2 diabetes, we found that metformin and dapagliflozin treatment resulted in significant weight loss but had no significant effect on EAT. Our findings suggest that the reported cardiovascular benefits of these two diabetic therapies are not likely to be mediated by effects on EAT.
| Item Type: | Conference Item (Paper) | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Global Heart | ||||||
| Publisher: | Elsevier | ||||||
| ISSN: | 2211-8179 | ||||||
| Official Date: | December 2018 | ||||||
| Dates: |
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| Volume: | 13 | ||||||
| Number: | 4 | ||||||
| Page Range: | p. 392 | ||||||
| DOI: | 10.1016/j.gheart.2018.09.060 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access | ||||||
| Conference Paper Type: | Paper | ||||||
| Title of Event: | World Congress of Cardiology & Cardiovascular Health 2018 | ||||||
| Type of Event: | Conference |
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