Boltze, Johannes, Lukomska, Barbara and Jolkkonen, Jukka (2014) Mesenchymal stromal cells in stroke : improvement of motor recovery or functional compensation? Journal of Cerebral Blood Flow & Metabolism, 34 (8). pp. 1420-1421. doi:10.1038/jcbfm.2014.94 ISSN 0271-678X.

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Abstract

Experimental stroke treatment by mesenchymal stem cell (MSC) populations is an attractive paradigm in stroke research. There are many studies describing improved functional outcomes after MSC delivery in stroke, but the mechanisms through which the transferred cells exert these effects are less well understood. Moreover, commonly applied functional tests may not be suitable for discriminating real functional recovery from compensation, which is a frequently encountered phenomenon in rodents. This commentary highlights some of the potential risks for the translational process associated with these tests and proposes some alternative test arrays which may achieve more specific functional phenotyping.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Journal or Publication Title:	Journal of Cerebral Blood Flow & Metabolism
Publisher:	Nature Publishing Group
ISSN:	0271-678X
Official Date:	1 August 2014
Dates:	Date Event 1 August 2014 Published
Volume:	34
Number:	8
Page Range:	pp. 1420-1421
DOI:	10.1038/jcbfm.2014.94
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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