Mueller, B., Ahnert, P., Burkhardt, J., Brauer, J., Czepezauer, I., Quente, E., Boltze, Johannes, Wilcke, A. and Kirsten, H. (2014) Genetic risk variants for dyslexia on chromosome 18 in a German cohort. Genes, Brain and Behavior, 13 (3). pp. 350-356. doi:10.1111/gbb.12118 ISSN 1601-1848.

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Abstract

Dyslexia is characterized by impaired reading and spelling. The disorder has a prevalence of about 5% in Germany, and a strong hereditary component. Several loci are thought to be involved in the development of dyslexia. Scerri et al. identified eight potential dyslexia‐associated single nucleotide polymorphisms (SNPs) in seven genes on chromosome 18 in an English‐speaking population. Here, we present an association analysis that explores the relevance of these SNPs in a German population comprising 388 dyslexia cases and 364 control cases. In case–control analysis, three nominal SNP associations were replicated. The major alleles of NEDD4L‐rs12606138 and NEDD4L‐rs8094327 were risk associated [odds ratio (OR) = 1.35, 95% confidence interval (CI) = 1.0–1.7, P‐value = 0.017 and OR = 1.39, 95% CI = 1.1–1.7, P‐value = 0.007, respectively], and both SNPs were in strong linkage disequilibrium (r2 = 0.95). For MYO5B‐rs555879, the minor allele was risk associated (OR = 1.31, 95% CI = 1.1–1.6, P‐value = 0.011). The combined analysis of SNP sets using set enrichment analysis revealed a study‐wide significant association for three SNPs with susceptibility for dyslexia. In summary, our results substantiate genetic markers in NEDD4L and MYO5B as risk factors for dyslexia and provide first evidence that the relevance of these markers is not restricted to the English language.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Journal or Publication Title:	Genes, Brain and Behavior
Publisher:	Wiley-Blackwell Publishing Ltd.
ISSN:	1601-1848
Official Date:	March 2014
Dates:	Date Event March 2014 Published
Volume:	13
Number:	3
Page Range:	pp. 350-356
DOI:	10.1111/gbb.12118
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)

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