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Stimuli-responsive membrane activity of cyclic-peptide–polymer conjugates
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Hartlieb, Matthias, Catrouillet, Sylvain, Kuroki, Agnès, Sanchez-Cano, Carlos, Peltier, Raoul and Perrier, Sébastien (2019) Stimuli-responsive membrane activity of cyclic-peptide–polymer conjugates. Chemical Science, 10 (21). pp. 5476-5483. doi:10.1039/C9SC00756C ISSN 2041-6520.
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Official URL: http://dx.doi.org/10.1039/C9SC00756C
Abstract
Cyclic peptide nanotubes (CPNT) consisting of an even number of amino acids with an alternating chirality are highly interesting materials in a biomedical context due to their ability to insert themselves into cellular membranes. However, unwanted unspecific interactions between CPNT and non-targeted cell membranes are a major drawback. To solve this issue we have synthetized a series of CPNT–polymer conjugates with a cleavable covalent connection between macromolecule and peptide. As a result, the polymers form a stabilizing and shielding shell around the nanotube that can be cleaved on demand to generate membrane active CPNT from non-active conjugates. This approach enables us to control the stacking and lateral aggregation of these materials, thus leading to stimuli responsive membrane activity. Moreover, upon activation, the systems can be adjusted to form nanotubes with an increased length instead of aggregates. We were able to study the dynamics of these systems in detail and prove the concept of stimuli responsive membrane interaction using CPNT–polymer conjugates to permeabilize liposomes as well as mammalian cell membranes.
Item Type: | Journal Article | ||||||||||||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Cyclic peptides, Nanostructured materials -- Research, Conjugated polymers, Polymers -- Materials -- Research | ||||||||||||||||||
Journal or Publication Title: | Chemical Science | ||||||||||||||||||
Publisher: | Royal Society of Chemistry | ||||||||||||||||||
ISSN: | 2041-6520 | ||||||||||||||||||
Official Date: | 28 June 2019 | ||||||||||||||||||
Dates: |
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Volume: | 10 | ||||||||||||||||||
Number: | 21 | ||||||||||||||||||
Page Range: | pp. 5476-5483 | ||||||||||||||||||
DOI: | 10.1039/C9SC00756C | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
Date of first compliant deposit: | 26 May 2021 | ||||||||||||||||||
Date of first compliant Open Access: | 26 May 2021 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
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