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Dyslexia risk gene relates to representation of sound in the auditory brainstem

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Neef, Nicole E., Müller, Bent, Liebig, Johanna, Schaadt, Gesa, Grigutsch, Maren, Gunter, Thomas C., Wilcke, Arndt, Kirsten, Holger, Skeide, Michael A., Kraft, Indra, Kraus, Nina, Emmrich, Frank, Brauer, Jens, Boltze, Johannes and Friederici, Angela D. (2017) Dyslexia risk gene relates to representation of sound in the auditory brainstem. Developmental Cognitive Neuroscience, 24 . pp. 63-71. doi:10.1016/j.dcn.2017.01.008

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Official URL: http://dx.doi.org/10.1016/j.dcn.2017.01.008

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Abstract

Dyslexia is a reading disorder with strong associations with KIAA0319 and DCDC2. Both genes play a functional role in spike time precision of neurons. Strikingly, poor readers show an imprecise encoding of fast transients of speech in the auditory brainstem. Whether dyslexia risk genes are related to the quality of sound encoding in the auditory brainstem remains to be investigated. Here, we quantified the response consistency of speech-evoked brainstem responses to the acoustically presented syllable [da] in 159 genotyped, literate and preliterate children. When controlling for age, sex, familial risk and intelligence, partial correlation analyses associated a higher dyslexia risk loading with KIAA0319 with noisier responses. In contrast, a higher risk loading with DCDC2 was associated with a trend towards more stable responses. These results suggest that unstable representation of sound, and thus, reduced neural discrimination ability of stop consonants, occurred in genotypes carrying a higher amount of KIAA0319 risk alleles. Current data provide the first evidence that the dyslexia-associated gene KIAA0319 can alter brainstem responses and impair phoneme processing in the auditory brainstem. This brain-gene relationship provides insight into the complex relationships between phenotype and genotype thereby improving the understanding of the dyslexia-inherent complex multifactorial condition.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
R Medicine > RJ Pediatrics
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Dyslexia, Reading disability, Brain stem, Auditory perception
Journal or Publication Title: Developmental Cognitive Neuroscience
Publisher: Elsevier
ISSN: 18789293
Official Date: April 2017
Dates:
DateEvent
April 2017Published
17 January 2017Available
15 January 2017Accepted
Date of first compliant deposit: 25 June 2019
Volume: 24
Page Range: pp. 63-71
DOI: 10.1016/j.dcn.2017.01.008
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDMax-Planck-Gesellschafthttp://dx.doi.org/10.13039/501100004189
UNSPECIFIEDFraunhofer-Gesellschafthttp://dx.doi.org/10.13039/501100003185
UNSPECIFIEDUniversität Leipzighttp://dx.doi.org/10.13039/501100008678

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