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Neuronal stem cell-drug interactions : a systematic review and meta-analysis
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Ikhsan, Maulana, Palumbo, Alex, Rose, Dorothee , Zille, Marietta and Boltze, Johannes (2019) Neuronal stem cell-drug interactions : a systematic review and meta-analysis. Stem Cells Translational Medicine, 8 (11). pp. 1202-1211. doi:10.1002/sctm.19-0020 ISSN 2157-6564.
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Official URL: https://doi.org/10.1002/sctm.19-0020
Abstract
Stem cell therapy is a promising treatment option for neurodegenerative diseases that mostly affect geriatric patients who often suffer from comorbidities requiring multiple medications. However, not much is known about the interactions between stem cells and drugs. Here, we focus on the potential interactions between drugs used to treat the comorbidities or sequelae of neurodegenerative diseases and neuronal stem cells to reveal potential effects on drug safety and efficacy. To determine the potential effects of drugs frequently used in geriatric patients (analgesic, antibiotic, antidepressant, antidiabetic, antihyperlipidemic, and antihypertensive drugs) on neuronal stem cell differentiation and proliferation, we systematically searched PubMed to identify nonreview articles published in English in peer‐reviewed journals between January 1, 1991, and June 7, 2018. We identified 5,954 publications, of which 214 were included. Only 62 publications provided the complete data sets required for meta‐analysis. We found that antidepressants stimulated neuronal stem cell proliferation but not differentiation under physiologic conditions and increased the proliferation of stem cells in the context of stress. Several other potential interactions were identified, but the limited number of available data sets precludes robust conclusions. Although available data were in most cases insufficient to perform robust meta‐analysis, a clear interaction between antidepressants and neuronal stem cells was identified. We reveal other potential interactions requiring further experimental investigation. We recommend that future research addresses such interactions and investigates the best combination of pharmacological interventions and neuronal stem cell treatments for more efficient and safer patient care. Stem Cells Translational Medicine 2019;8:1202–1211
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QH Natural history > QH426 Genetics | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
Library of Congress Subject Headings (LCSH): | Stem cells, Stem cells -- Research, Stem cells -- Therapeutic use, Drug interactions | ||||||||
Journal or Publication Title: | Stem Cells Translational Medicine | ||||||||
Publisher: | Wiley-Blackwell Publishing, Inc | ||||||||
ISSN: | 2157-6564 | ||||||||
Official Date: | November 2019 | ||||||||
Dates: |
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Volume: | 8 | ||||||||
Number: | 11 | ||||||||
Page Range: | pp. 1202-1211 | ||||||||
DOI: | 10.1002/sctm.19-0020 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 24 June 2019 | ||||||||
Date of first compliant Open Access: | 28 June 2019 | ||||||||
RIOXX Funder/Project Grant: |
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