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Disturbed Yin-Yang balance : stress increases the susceptibility to herpes simplex virus type 1 primary and recurrent infections

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Yan, Chang, Luo, Zhuo, Li, Wen, Li, Xue, Dallmann, Robert, Kurihara, Hiroshi, Li, Yi-Fang and He, Rong-Rong (2020) Disturbed Yin-Yang balance : stress increases the susceptibility to herpes simplex virus type 1 primary and recurrent infections. Acta Pharmaceutica Sinica B, 10 (3). pp. 383-398. doi:10.1016/j.apsb.2019.06.005

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Official URL: https://doi.org/10.1016/j.apsb.2019.06.005

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Abstract

Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, is able to establish a lifelong latent infection in the human host. Following primary replication in mucosal epithelial cells, the virus can enter sensory neurons innervating peripheral tissues via nerve termini. The viral genome is then transported to the nucleus where it can be maintained without producing infectious progeny, and thus latency is established in the cell. Yin–Yang balance is an essential concept in traditional Chinese medicine (TCM) theory. Yin represents stable and inhibitory factors, and Yang represents the active and aggressive factors. When the organism is exposed to stress, especially psychological stress caused by emotional stimulation, the Yin–Yang balance is disturbed and the virus can re-engage in productive replication, resulting in recurrent diseases. Therefore, a better understanding of the stress-induced susceptibility to HSV-1 primary infection and reactivation is needed and will provide helpful insights into the effective control and treatment of HSV-1. Here we reviewed the recent advances in the studies of HSV-1 susceptibility, latency and reactivation. We included mechanisms involved in primary infection and the regulation of latency and described how stress-induced changes increase the susceptibility to primary and recurrent infections.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Herpes simplex virus , Medicine, Chinese
Journal or Publication Title: Acta Pharmaceutica Sinica B
Publisher: Elsevier
ISSN: 2211-3835
Official Date: March 2020
Dates:
DateEvent
March 2020Published
22 June 2019Available
31 May 2019Accepted
Volume: 10
Number: 3
Page Range: pp. 383-398
DOI: 10.1016/j.apsb.2019.06.005
Status: Peer Reviewed
Publication Status: Published
Reuse Statement (publisher, data, author rights): ** Article version: AM ** From Elsevier via Jisc Publications Router ** History: accepted 18-06-2019; issue date 22-06-2019. ** Licence for AM version of this article starting on 20-06-2019: http://creativecommons.org/licenses/by-nc-nd/4.0/
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
2017YFC1700404National Key Research and Development Program of China Stem Cell and Translational ResearchUNSPECIFIED
81622050[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
81573675[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
81673709[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
81560661[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
81873209[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
2014TQ01R229Young Top notch Talent Support Program of Guangdong Province, ChinaUNSPECIFIED
2016TQ03R586)Young Top notch Talent Support Program of Guangdong Province, ChinaUNSPECIFIED
A201701A02Administration of Ocean and Fisheries of Guangdong ProvinceUNSPECIFIED
2017A030306004Medical Science and Technology Foundation of Guangdong Provincehttp://dx.doi.org/10.13039/501100009330
201604046016Science and Technology Program of Guangzhou, ChinaUNSPECIFIED
201610010182Science and Technology Program of Guangzhou, ChinaUNSPECIFIED

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