The Library
Disturbed Yin-Yang balance : stress increases the susceptibility to herpes simplex virus type 1 primary and recurrent infections
Tools
Tools
Tools
Yan, Chang, Luo, Zhuo, Li, Wen, Li, Xue, Dallmann, Robert, Kurihara, Hiroshi, Li, Yi-Fang and He, Rong-Rong (2020) Disturbed Yin-Yang balance : stress increases the susceptibility to herpes simplex virus type 1 primary and recurrent infections. Acta Pharmaceutica Sinica B, 10 (3). pp. 383-398. doi:10.1016/j.apsb.2019.06.005
|
PDF
WRAP-disturbed-Yin-Yang-balance-stress-increases-infections-herpes-virus-Dallmann-2019.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2817Kb) | Preview |
Official URL: https://doi.org/10.1016/j.apsb.2019.06.005
Abstract
Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, is able to establish a lifelong latent infection in the human host. Following primary replication in mucosal epithelial cells, the virus can enter sensory neurons innervating peripheral tissues via nerve termini. The viral genome is then transported to the nucleus where it can be maintained without producing infectious progeny, and thus latency is established in the cell. Yin–Yang balance is an essential concept in traditional Chinese medicine (TCM) theory. Yin represents stable and inhibitory factors, and Yang represents the active and aggressive factors. When the organism is exposed to stress, especially psychological stress caused by emotional stimulation, the Yin–Yang balance is disturbed and the virus can re-engage in productive replication, resulting in recurrent diseases. Therefore, a better understanding of the stress-induced susceptibility to HSV-1 primary infection and reactivation is needed and will provide helpful insights into the effective control and treatment of HSV-1. Here we reviewed the recent advances in the studies of HSV-1 susceptibility, latency and reactivation. We included mechanisms involved in primary infection and the regulation of latency and described how stress-induced changes increase the susceptibility to primary and recurrent infections.
| Item Type: | Journal Article | |||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology > QR355 Virology | |||||||||||||||||||||||||||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
|||||||||||||||||||||||||||||||||||||||
| SWORD Depositor: | Library Publications Router | |||||||||||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Herpes simplex virus , Medicine, Chinese | |||||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Acta Pharmaceutica Sinica B | |||||||||||||||||||||||||||||||||||||||
| Publisher: | Elsevier | |||||||||||||||||||||||||||||||||||||||
| ISSN: | 2211-3835 | |||||||||||||||||||||||||||||||||||||||
| Official Date: | March 2020 | |||||||||||||||||||||||||||||||||||||||
| Dates: |
|
|||||||||||||||||||||||||||||||||||||||
| Volume: | 10 | |||||||||||||||||||||||||||||||||||||||
| Number: | 3 | |||||||||||||||||||||||||||||||||||||||
| Page Range: | pp. 383-398 | |||||||||||||||||||||||||||||||||||||||
| DOI: | 10.1016/j.apsb.2019.06.005 | |||||||||||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||||||||||||||||||||
| Reuse Statement (publisher, data, author rights): | ** Article version: AM ** From Elsevier via Jisc Publications Router ** History: accepted 18-06-2019; issue date 22-06-2019. ** Licence for AM version of this article starting on 20-06-2019: http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||||||||||||||||||||||||
| Access rights to Published version: | Open Access | |||||||||||||||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
