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Pneumococcal disease : a systematic review of health utilities, resource use, costs, and economic evaluations of interventions
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Shiri, T., Kamran, K., Keaney, K., Mukherjee, G., McCarthy, Noel D. and Petrou, Stavros (2019) Pneumococcal disease : a systematic review of health utilities, resource use, costs, and economic evaluations of interventions. Value in Health, 22 (11). pp. 1329-1344. doi:10.1016/j.jval.2019.06.011
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Official URL: https://doi.org/10.1016/j.jval.2019.06.011
Abstract
Background
Pneumococcal diseases cause substantial mortality, morbidity, and economic burden. Evidence on data inputs for economic evaluations of interventions targeting pneumococcal disease is critical.
Objectives
To summarize evidence on resource use, costs, health utilities, and cost-effectiveness for pneumococcal disease and associated interventions to inform future economic analyses.
Methods
We searched MEDLINE, Embase, Web of Science, CINAHL, PsycINFO, EconLit, and Cochrane databases for peer-reviewed studies in English on pneumococcal disease that reported health utilities using direct or indirect valuation methods, resource use, costs, or cost-effectiveness of intervention programs, and summarized the evidence descriptively.
Results
We included 383 studies: 9 reporting health utilities, 131 resource use, 160 economic costs of pneumococcal disease, 95 both resource use and costs, and 178 economic evaluations of pneumococcal intervention programs. Health state utility values ranged from 0 to 1 for both meningitis and otitis media and from 0.3 to 0.7 for both pneumonia and sepsis. Hospitalization was shortest for otitis media (range: 0.1-5 days) and longest for sepsis/septicemia (6-48). The main categories of costs reported were drugs, hospitalization, and household or employer costs. Resource use was reported in hospital length of stay and number of contacts with general practitioners. Costs and resource use significantly varied among population ages, disease conditions, and settings. Current vaccination programs for both adults and children, antibiotic use and outreach programs to promote vaccination, early disease detection, and educational programs are cost-effective in most countries.
Conclusion
This study has generated a comprehensive repository of health economic evidence on pneumococcal disease that can be used to inform future economic evaluations of pneumococcal disease intervention programs.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Value in Health | ||||||||
| Publisher: | Elsevier | ||||||||
| ISSN: | 1098-3015 | ||||||||
| Official Date: | November 2019 | ||||||||
| Dates: |
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| Date of first compliant deposit: | 1 July 2019 | ||||||||
| Volume: | 22 | ||||||||
| Number: | 11 | ||||||||
| Page Range: | pp. 1329-1344 | ||||||||
| DOI: | 10.1016/j.jval.2019.06.011 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
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