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Micronutrient deficiencies and health-related quality of life: the case of children with vitamin D deficiency
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Aguiar, Magda, Andronis, Lazaros, Pallan, Miranda, Högler, Wolfgang and Frew, Emma (2020) Micronutrient deficiencies and health-related quality of life: the case of children with vitamin D deficiency. Public Health Nutrition, 23 (7). pp. 1165-1172. doi:10.1017/S1368980018003841
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Official URL: http://dx.doi.org/10.1017/S1368980018003841
Abstract
Objective
To explore the extent to which micronutrient deficiencies (MND) affect children’s health-related quality of life (HRQoL), using vitamin D deficiency (VDD) as a case study.
Design
Proxy valuation study to estimate the impact of VDD on the HRQoL of younger (0–4 years) and older (>4 years) children. We used the Child Health Utility 9 Dimension (CHU9D) questionnaire to estimate HRQoL for children within six VDD-related health states: ‘hypocalcaemic cardiomyopathy’, ‘hypocalcaemic seizures’, ‘active rickets’, ‘bone deformities’, ‘pain and muscle weakness’ and ‘subclinical VDD’.
Setting
Sampling was not restricted to any particular setting and worldwide experts were recruited.
Participants
Respondents were paediatric bone experts recruited through network sampling.
Results
Thirty-eight experts completed the survey. The health state with the largest detrimental impact (mean score (se)) on children’s HRQoL was hypocalcaemic cardiomyopathy (0·47 (0·02)), followed by hypocalcaemic seizures (0·50 (0·02)) and active rickets (0·62 (0·02) in young children; 0·57 (0·02) in older children). Asymptomatic VDD had a modest but noticeable negative impact on HRQoL, attributed mostly to tiredness in both age groups and pain in the older paediatric population.
Conclusions
Elicitation of HRQoL from clinical experts suggests a negative impact of VDD on HRQoL, even if there is no recognizable clinical manifestation. HRQoL data from populations of patients with MND will inform public health policy decisions. In some settings, routine collection of HRQoL data alongside national nutrition surveys may help capture the full burden of MND and prioritize resources towards effective prevention.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences | ||||||
| Journal or Publication Title: | Public Health Nutrition | ||||||
| Publisher: | Cambridge University Press | ||||||
| ISSN: | 1368-9800 | ||||||
| Official Date: | May 2020 | ||||||
| Dates: |
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| Volume: | 23 | ||||||
| Number: | 7 | ||||||
| Page Range: | pp. 1165-1172 | ||||||
| DOI: | 10.1017/S1368980018003841 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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