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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
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(2019) Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nature Genetics, 51 (2). pp. 245-257. doi:10.1038/s41588-018-0309-3 ISSN 1061-4036.
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WRAP-genome-wide-association-risk-tolerance-one-hundreds-Cappuccio-2019.pdf - Accepted Version - Requires a PDF viewer. Download (1933Kb) | Preview |
Official URL: http://dx.doi.org/10.1038/s41588-018-0309-3
Abstract
Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated (|r^g| ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||
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Subjects: | H Social Sciences > HV Social pathology. Social and public welfare Q Science > Q Science (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Genomes, Genetics, Automobile driving -- Health aspects, Drinking behavior, Smoking -- Health aspects, Sex, Educational attainment -- Genetic aspects | ||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Nature Genetics | ||||||||||||||||||||||||||||||||||||
Publisher: | Nature Publishing Group | ||||||||||||||||||||||||||||||||||||
ISSN: | 1061-4036 | ||||||||||||||||||||||||||||||||||||
Official Date: | February 2019 | ||||||||||||||||||||||||||||||||||||
Dates: |
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Volume: | 51 | ||||||||||||||||||||||||||||||||||||
Number: | 2 | ||||||||||||||||||||||||||||||||||||
Page Range: | pp. 245-257 | ||||||||||||||||||||||||||||||||||||
DOI: | 10.1038/s41588-018-0309-3 | ||||||||||||||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||||||||||||||||||||
Date of first compliant deposit: | 30 September 2019 | ||||||||||||||||||||||||||||||||||||
Date of first compliant Open Access: | 30 September 2019 | ||||||||||||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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